Skip to Content
Merck
CN

GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Synonyms:
DMRV, GLCNE, IBM2, NM, Uae1
Species:
Human GNE (10020), Mouse Gne (50798), Rat Gne (114711), Zebrafish gne (393857), chicken GNE (427285), dog GNE (481607), Horse GNE (100067216), domestic cat GNE (101098411), sheep GNE (101110735), cow GNE (782201) ...More
UniProtKB ID:
Q9Y223, A6PZH2, A6PZH3, A7UNU7, B2R6E1, B7Z372, B7Z428, D3DRP7
Gene ID:
  • Human(10020) Summary: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(50798) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Rat(114711) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Zebrafish(393857) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • chicken(427285) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • dog(481607) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Horse(100067216) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • domestic cat(101098411) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • sheep(101110735) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • cow(782201) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • Domestic Rabbit(100340455) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • naked mole-rat(101705910) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • domestic guinea pig(100731383) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
HPA007045
Anti-GNE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
HPA027258
Anti-GNE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
SAB6012080
Anti GNE Antibody, clone 23GB5560, Rabbit Monoclonal, clone 23GB5560, recombinant rabbit monoclonal, expressed in HEK293 cells,
Species Reactivity
human
Application
western blot

esiRNA

Product Number
Description
Species
EHU019551
MISSION® esiRNA, targeting human GNE,
Species
human
EMU057121
MISSION® esiRNA, targeting mouse Gne,
Species
mouse