ITCH
itchy E3 ubiquitin protein ligase
Synonyms:
AIF4, AIP4, NAPP1, dJ468O1.1
Species:
Human ITCH (83737), Mouse Itch (16396), Rat Itch (311567), chicken ITCH (419145), Zebrafish itch (100331274), cow ITCH (508431), dog ITCH (477199), domestic guinea pig Itch (100724288), Horse ITCH (100069340), domestic cat ITCH (101086133) ...More
UniProtKB ID:
Gene ID:
- Human(83737) Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
- Mouse(16396) itchy, E3 ubiquitin protein ligase
- Rat(311567) itchy E3 ubiquitin protein ligase
- chicken(419145) itchy E3 ubiquitin protein ligase
- Zebrafish(100331274) itchy E3 ubiquitin protein ligase homolog (mouse)
- cow(508431) itchy E3 ubiquitin protein ligase homolog (mouse)
- dog(477199) itchy E3 ubiquitin protein ligase
- domestic guinea pig(100724288) itchy E3 ubiquitin protein ligase
- Horse(100069340) itchy E3 ubiquitin protein ligase
- domestic cat(101086133) itchy E3 ubiquitin protein ligase
- sheep(101118041) itchy E3 ubiquitin protein ligase
- naked mole-rat(101711522) itchy E3 ubiquitin protein ligase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ITCH antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, monkey
Application
western blot
Anti-ITCH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti- ITCH antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti- ITCH antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti ITCH Antibody, clone 23GB6255, Rabbit Monoclonal, clone 23GB6255, recombinant rabbit monoclonal, expressed in HEK293 cells,
Species Reactivity
human, rat
Application
flow cytometry
western blot
western blot