Merck
CN

PDE6B

phosphodiesterase 6B, cGMP-specific, rod, beta

别名:
CSNB3, CSNBAD2, PDEB, RP40, rd1
物种:
Human PDE6B (5158), Mouse Pde6b (18587), Rat Pde6b (289878), sheep PDE6B (101108490), domestic guinea pig Pde6b (100721588), naked mole-rat Pde6b (101705017), chicken PDE6B (395092), Zebrafish pde6b (559332), dog PDE6B (399653), cow PDE6B (281974)
UniProtKB ID:
P35913, B7Z9T9, E7ETT3, Q53XN5, Q9BWH5, Q9UD49
基因ID:
  • Human(5158) Summary: Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
  • Mouse(18587) phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
  • Rat(289878) phosphodiesterase 6B, cGMP-specific, rod, beta
  • sheep(101108490) phosphodiesterase 6B, cGMP-specific, rod, beta
  • domestic guinea pig(100721588) phosphodiesterase 6B, cGMP-specific, rod, beta
  • naked mole-rat(101705017) phosphodiesterase 6B, cGMP-specific, rod, beta
  • chicken(395092) phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)
  • Zebrafish(559332) phosphodiesterase 6B, cGMP-specific, rod, beta
  • dog(399653) phosphodiesterase 6B, cGMP-specific, rod, beta
  • cow(281974) phosphodiesterase 6B, cGMP-specific, rod, beta
  • domestic cat(101095012) phosphodiesterase 6B, cGMP-specific, rod, beta

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Antibodies

货号
说明
物种反应性
应用
HPA059929
Anti-PDE6B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
HPA054148
Anti-PDE6B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry

Small Molecule - Inhibitor

货号
说明
物种
Y0000802
双嘧达莫, European Pharmacopoeia (EP) Reference Standard,
物种
human
1220506
双嘧达莫, United States Pharmacopeia (USP) Reference Standard,
物种
human
D2850000
双嘧达莫, European Pharmacopoeia (EP) Reference Standard,
物种
human
BP131
双嘧达莫, British Pharmacopoeia (BP) Reference Standard,
物种
human
BP1102
双嘧达莫杂质标准品, British Pharmacopoeia (BP) Reference Standard,
物种
human

esiRNA

货号
说明
物种
EMU005391
MISSION® esiRNA, targeting mouse Pde6b,
物种
mouse
EHU044031
MISSION® esiRNA, targeting human PDE6B,
物种
human