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Merck
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PTS

6-pyruvoyltetrahydropterin synthase

Synonyms:
PTPS
Species:
UniProtKB ID:
Gene ID:
  • Human(5805) Summary: The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]
  • Mouse(19286) 6-pyruvoyl-tetrahydropterin synthase
  • Rat(29498) 6-pyruvoyl-tetrahydropterin synthase
  • fruit fly(252458) ponte thermosensible
  • Zebrafish(100073330) 6-pyruvoyltetrahydropterin synthase
  • chicken(374144) 6-pyruvoyltetrahydropterin synthase
  • dog(611326) 6-pyruvoyltetrahydropterin synthase
  • domestic cat(101096347) 6-pyruvoyltetrahydropterin synthase
  • cow(506860) 6-pyruvoyltetrahydropterin synthase
  • sheep(101108950) 6-pyruvoyltetrahydropterin synthase
  • domestic guinea pig(100733894) 6-pyruvoyltetrahydropterin synthase
  • naked mole-rat(101705212) 6-pyruvoyltetrahydropterin synthase

Custom & Knockdown Gene Products

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-PTS (Ser19) Antibody, clone 24GB800, Rabbit Monoclonal, clone 24GB800, recombinant rabbit monoclonal, expressed in HEK293 cells,
Species Reactivity
human, rat
Application
flow cytometry
immunofluorescence

western blot
Anti-PTS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Pts,
Species
mouse
MISSION® esiRNA, targeting human PTS,
Species
human