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Merck
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SETD2

SET domain containing 2

Synonyms:
HBP231, HIF-1, HIP-1, HYPB, KMT3A, SET2, p231HBP
Species:
UniProtKB ID:
Gene ID:
  • Human(29072) Summary: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
  • Mouse(235626) SET domain containing 2
  • Rat(316013) SET domain containing 2
  • cow(539860) SET domain containing 2
  • Horse(100064888) SET domain containing 2
  • naked mole-rat(101719404) SET domain containing 2
  • domestic guinea pig(100719166) SET domain containing 2
  • chicken(420404) SET domain containing 2
  • Zebrafish(794199) SET domain containing 2
  • domestic cat(101085029) SET domain containing 2
  • dog(476643) SET domain containing 2

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SETD2 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL9956, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-SETD2 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-SETD2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-SETD2 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
western blot
Anti-SETD2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, pig
Application
ELISA
western blot

Proteins

Product Number
Description
Species
Set2 human, recombinant, expressed in E. coli, ≥75% (SDS-PAGE),
Species
human
SETD2 active human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Setd2,
Species
mouse
MISSION® esiRNA, targeting human SETD2,
Species
human