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SIRT1

sirtuin 1

别名:

SIR2L1

物种:

Human SIRT1 (23411), Mouse Sirt1 (93759), Rat Sirt1 (309757), cow SIRT1 (613629), naked mole-rat Sirt1 (101720282), dog SIRT1 (489012), domestic cat SIRT1 (101087610), chicken SIRT1 (423646), Zebrafish sirt1 (797132), domestic guinea pig Sirt1 (100717014) ...展开

UniProtKB ID:

Q96EB6, Q2XNF6, Q5JVQ0, Q9GZR9, Q9Y6F0

基因ID:

Human(23411) Summary: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Mouse(93759) sirtuin 1
Rat(309757) sirtuin 1
cow(613629) sirtuin 1
naked mole-rat(101720282) sirtuin 1
dog(489012) sirtuin 1
domestic cat(101087610) sirtuin 1
chicken(423646) sirtuin 1
Zebrafish(797132) sirtuin (silent mating type information regulation 2 homolog) 1
domestic guinea pig(100717014) sirtuin 1
sheep(101102956) sirtuin 1
Domestic Rabbit(100349271) sirtuin 1
Horse(100072571) sirtuin 1

产品 (35)
同行评审论文 (3,529)

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ELISA

Product Number

说明

物种

人SIRT1 ELISA, ,

物种

human

Small Molecule - Activator

Product Number

说明

物种

白藜芦醇, ≥99% (HPLC),

物种

human, rat, mouse

Activity Assay

Product Number

说明

物种

SIRT1 检测试剂盒, sufficient for 100 assays,

物种

human

Antibodies

Product Number

说明

物种反应性

应用

抗SIRT1抗体，克隆10E4, clone 10-E-4, from mouse,

物种反应性

human, mouse

应用

ChIP
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot

Anti-SIRT1 antibody produced in rabbit, ,

物种反应性

human, mouse, rat

应用

immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot

Anti-Sirt1 antibody, Mouse monoclonal, clone SIR11, purified from hybridoma cell culture,

物种反应性

mouse

应用

ELISA
microarray
western blot

抗-SIRT1 兔抗, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,

物种反应性

human

应用

immunofluorescence
immunohistochemistry

Anti-phospho SIRT1 (Ser682) Antibody, from rabbit, purified by affinity chromatography,

物种反应性

bovine, feline, human, mouse, porcine

应用

western blot

Small Molecule - Inhibitor

Product Number

说明

物种

Sirtinol, ≥95% (HPLC),

物种

human

白藜芦醇, ≥99% (HPLC),

物种

human, rat, mouse

Proteins

Product Number

说明

物种

Sirtuin 1 human, recombinant, expressed in E. coli, ≥60% (SDS-PAGE),

物种

human

SIRT1 人, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), buffered aqueous glycerol solution,

物种

human

SIRT1, active, His tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,

物种

human

esiRNA

Product Number

说明

物种

MISSION^® 长非编码 esiRNA, targeting human SIRT1 (1),

物种

human

MISSION^® 长非编码 esiRNA, targeting human SIRT1 (2),

物种

human

MISSION^® esiRNA, targeting mouse Sirt1,

物种

mouse