CN
SREBF1
sterol regulatory element binding transcription factor 1
别名:
SREBP-1c, SREBP1, bHLHd1
物种:
Human SREBF1 (6720), Mouse Srebf1 (20787), Rat Srebf1 (78968), chicken SREBF1 (373915), domestic cat SREBF1 (101087535), dog SREBF1 (403475), Horse SREBF1 (100052283), sheep SREBF1 (100329218), Goat SREBF1 (100860908), cow SREBF1 (539361) ...展开
UniProtKB ID:
基因ID:
- Human(6720) Summary: This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(20787) sterol regulatory element binding transcription factor 1
- Rat(78968) sterol regulatory element binding transcription factor 1
- chicken(373915) sterol regulatory element binding transcription factor 1
- domestic cat(101087535) sterol regulatory element binding transcription factor 1
- dog(403475) sterol regulatory element binding transcription factor 1
- Horse(100052283) sterol regulatory element binding transcription factor 1
- sheep(100329218) sterol regulatory element binding transcription factor 1
- Goat(100860908) sterol regulatory element binding transcription factor 1
- cow(539361) sterol regulatory element binding transcription factor 1
- domestic guinea pig(100731641) sterol regulatory element binding transcription factor 1
- naked mole-rat(101705277) sterol regulatory element binding transcription factor 1
- Zebrafish(793274) sterol regulatory element binding transcription factor 1
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Antibodies
货号
说明
物种反应性
应用
Anti-SREBP-1 Antibody, clone 20B12, clone 20B12, from rabbit,
物种反应性
human, mouse
应用
western blot
Anti-SREBP1 Antibody, clone 2D21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human
应用
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
抗 SREBP-1 兔抗, affinity isolated antibody,
物种反应性
human, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-SREBP-1 Antibody, clone 2A4, clone 2A4, from mouse,
物种反应性
canine, hamster, human
应用
western blot