CN
TERT
telomerase reverse transcriptase
别名:
CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT
物种:
Human TERT (7015), Mouse Tert (21752), Rat Tert (301965), domestic guinea pig Tert (100732437), chicken TERT (420972), Zebrafish tert (796551), naked mole-rat Tert (101706965), domestic cat TERT (100144612), cow TERT (518884), sheep TERT (100126866) ...展开
UniProtKB ID:
基因ID:
- Human(7015) Summary: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
- Mouse(21752) telomerase reverse transcriptase
- Rat(301965) telomerase reverse transcriptase
- domestic guinea pig(100732437) telomerase reverse transcriptase
- chicken(420972) telomerase reverse transcriptase
- Zebrafish(796551) telomerase reverse transcriptase
- naked mole-rat(101706965) telomerase reverse transcriptase
- domestic cat(100144612) telomerase reverse transcriptase
- cow(518884) telomerase reverse transcriptase
- sheep(100126866) telomerase reverse transcriptase
- sheep(101112422) telomerase reverse transcriptase
- dog(403412) telomerase reverse transcriptase
- Thale Cress(831548) telomerase reverse transcriptase
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Antibodies
货号
说明
物种反应性
应用
抗-TERT抗体, from rabbit, purified by affinity chromatography,
物种反应性
human, mouse, rat, rhesus macaque
应用
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TERT Antibody, clone 7D5.2, clone 7D5.2, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-Telomerase antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
ELISA
western blot
western blot
Anti-TERT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
抗-TERT（人）抗体，克隆2C4, clone 2C4, from mouse,
物种反应性
human
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Small Molecule - Inhibitor
esiRNA
货号
说明
物种