TPCN2
two pore segment channel 2
Synonyms:
SHEP10, TPC2
Species:
Human TPCN2 (219931), Mouse Tpcn2 (233979), Rat Tpcn2 (309139), domestic guinea pig Tpcn2 (100729259), Zebrafish tpcn2 (777614), dog TPCN2 (483683), chicken TPCN2 (423141), cow TPCN2 (516679), naked mole-rat Tpcn2 (101712986), domestic cat TPCN2 (101086345)
UniProtKB ID:
Gene ID:
- Human(219931) Summary: This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]
- Mouse(233979) two pore segment channel 2
- Rat(309139) two pore segment channel 2
- domestic guinea pig(100729259) two pore segment channel 2
- Zebrafish(777614) two pore segment channel 2
- dog(483683) two pore segment channel 2
- chicken(423141) two pore segment channel 2
- cow(516679) two pore segment channel 2
- naked mole-rat(101712986) two pore segment channel 2
- domestic cat(101086345) two pore segment channel 2
- sheep(101115493) two pore segment channel 2
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