202509
聚乙二醇甲基醚
average Mn 2,000, methoxy, hydroxyl
别名:
mPEG, 甲氧基聚乙二醇, 聚乙二醇单甲醚
产品名称
聚乙二醇甲基醚, average Mn ~2,000
蒸汽密度
>1 (vs air)
质量水平
蒸汽压
0.05 mmHg ( 20 °C)
表单
flakes (or pellets)
分子量
average Mn ~2,000
粘度
54.6 cSt(210 °F)(lit.)
转变温度
Tm 52 °C
官能团
hydroxyl
SMILES字符串
O(CCO)C
InChI
1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
InChI key
XNWFRZJHXBZDAG-UHFFFAOYSA-N
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一般描述
它是聚乙二醇（PEG）大分子单体，具有由甲基醚组成的反应性链端。PEG链末端的醚化可以通过在碱性条件下使其与烷基卤化物进行反应来实现。mPEG可以进行交联以形成水凝胶;聚合反应可以通过氧化还原反应或自由基引发剂进行引发。
应用
插入聚（乙二醇）甲基醚结合的树状聚合物可作为抗癌药物的载体。这种新型药物载体具有生物相容性表面和药物的内部封装。
它可作为一种成孔剂，以制备用于去除大分子的超滤膜。
还可将其作为起始材料，用于制备生物可降解的聚（L-丙氨酸）与mPEG的两亲性共聚物。
它可作为一种成孔剂，以制备用于去除大分子的超滤膜。
还可将其作为起始材料，用于制备生物可降解的聚（L-丙氨酸）与mPEG的两亲性共聚物。
特点和优势
插入聚（乙二醇）甲基醚(mPEG)侧链可增强聚合物基质的亲水性和柔韧性。
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
359.6 °F - closed cup
闪点(°C)
182 °C - closed cup
个人防护装备
Eyeshields, Gloves
Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Lina Du et al.
Anti-cancer drugs, 24(2), 172-180 (2012-09-20)
A functionalized poly(amidoamine) (PAMAM) nanocarrier was designed and prepared to deliver anticancer drugs. The nanocarrier is a copolymer with a core-shell structure with 3.0 G PAMAM as the core and sequentially conjugated poly(2-(N,N-diethylamino)ethyl methacrylate) (pDEA) and methoxy-poly(ethylene glycol) 2000 (mPEG)
Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Junming Li et al.
Journal of biomedical nanotechnology, 8(5), 809-817 (2012-08-15)
In this study, quercetin (QC) with cancer chemoprevention effect and anticancer potential was loaded into polymeric micelles of methoxy poly(ethylene glycol)-cholesterol conjugate (mPEG-Chol) in order to increase its water solubility. MPEG-Chol with lower critical micelle concentration (CMC) value (4.0 x
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
商品
Biofouling control essential for device performance and safety; minimize accumulation of biomolecules and bioorganisms.
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