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About This Item
Empirical Formula (Hill Notation):
C45H77BF2N3O8P
CAS Number:
Molecular Weight:
867.89
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
Product Name
TopFluor™ PE, Avanti Research™ - A Croda Brand 810282C
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810282C-1mg)
pkg of 5 × 1 mL (810282C-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810282C
concentration
1 mg/mL (810282C-1mg)
1 mg/mL (810282C-5mg)
shipped in
dry ice
storage temp.
−20°C
Application
TopFluor™ PE may be used as a fluorescently labeled lipid to replace the head labeled lipid (TFPE-head) to study the fusion efficiency of liposomes. It has also been used in the preparation of liposome.
Biochem/physiol Actions
Phosphoethanolamine participates in phospholipid metabolism. It has the ability to repress tumor growth both in vitro and in vivo.
General description
TopFluor has a moiety, called dipyrromethene boron difluoride. This fluorescent molecule is covalently attached to various lipid molecules. Phosphoethanolamine is a precursor to phosphatidylcholine and phosphatidylethanolamine.
Packaging
5 mL Amber Glass Screw Cap Vial (810282C-1mg)
5 mL Amber Glass Screw Cap Vial (810282C-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system, Liver,Kidney
wgk
WGK 3
Regulatory Information
易制毒化学品（2类）
危险化学品
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Fumonisin, Folate, and Neural Tube Defects
Comprehensive Toxicology, 12, 189-208 (2010)
Influence of Environmental Conditions on the Fusion of Cationic Liposomes with Living Mammalian Cells
Kolasinac R, et al.
Nanomaterials, 9(7), 1025-1025 (2019)
Phosphoethanolamine and the danger of unproven drugs
Pondee N, et al.
Ecancermedicalscience (2016)
Single Particle Fluorescence Burst Analysis of Epsin Induced Membrane Fission
Brooks A, et al.
Testing, 10(3) (2015)
Pei Qiao et al.
Biochemistry, 59(22), 2089-2099 (2020-05-07)
Activation of G-protein-gated inwardly rectifying potassium channels (Kir3.x) requires the direct binding of phosphorylated phosphatidylinositides (PIPs). Previous studies have established that PIP isoforms activate Kir channels to varying degrees and the binding affinity between PIPs and Kir3.2 appears to be
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