产品名称
18:0 PC (DSPC), Avanti Research™ - A Croda Brand
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
InChI
1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1
InChI key
NRJAVPSFFCBXDT-HUESYALOSA-N
description
1,2-distearoyl-sn-glycero-3-phosphocholine
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (850365P-1G)
pkg of 1 × 200 mg (850365P-200MG)
pkg of 1 × 25 mg (850365P-25MG)
pkg of 1 × 500 mg (850365P-500MG)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
advanced drug delivery
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
Application
18：0 PC（DSPC）用于：
- 制备微泡单层的过程中，研究将生物分子递送至原生质体的机理
- 制备脂质体，进行固定化研究
- 制备由伊立替康（IRT）和阿霉素递送的卟啉-磷脂（PoP）脂质体
Biochem/physiol Actions
1,2-二硬脂酰-sn-甘油-3-磷酸胆碱（DSPC）与磷脂酰胆碱家族的其他成员结合使用，可生成混合双层系统。 主要用于制备常规和隐形脂质体，进行药物递送研究。
General description
1,2-二硬脂酰-sn-甘油-3-磷酸胆碱（DSPC）是含18碳烷基链的磷脂酰胆碱。 具有磷脂酰胆碱头部基团，其结构与1,2-二棕榈酰-sn-甘油-3-磷脂酰胆碱（DPPC）相似。
Avanti 提供的磷脂酰胆碱产品旨在提供具有多种物理属性的化合物。可用产品包括短链（C3-C8 具有水溶性和吸湿性）、饱和、多不饱和和混合酸 PC。所有产物均采用 HPLC 法纯化，并采取特殊措施保护产品的氧化和水解。
Packaging
20 mL透明玻璃螺旋盖小瓶（850365P-1G）
20 mL透明玻璃螺旋盖小瓶（850365P-500MG）
5 mL棕色玻璃螺旋盖小瓶（850365P-200MG）
5 mL棕色玻璃螺旋盖小瓶（850365P-25MG）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Investigating the structure of multicomponent gel-phase lipid bilayers
Hartkamp R, et al.
Biophysical Journal, 111(4), 813-823 (2016)
Comparative study of PEGylated and conventional liposomes as carriers for shikonin
Tsermentseli S, et al.
Fluids, 3(2), 36-36 (2018)
A coarse-grained molecular dynamics study of DLPC, DMPC, DPPC, and DSPC mixtures in aqueous solution
Abedi K, et al.
Journal of Chemistry, 2013 (2013)
Tadaharu Suga et al.
Molecular pharmaceutics, 15(10), 4481-4490 (2018-09-05)
High-functionality and -quality (HFQ) lipids have a discrete molecular weight and good water dispersibility and can be produced by solid-phase peptide synthesis. Therefore, HFQ lipids are a promising material for the preparation of ligand-grafted PEGylated liposomes. Recently, we have reported
Ana Reis et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183133-183133 (2019-12-01)
Food polyphenols in fruits juices, tea, coffee, wine and beer confer sensory properties such as colour, astringency and bitterness. The development of functional healthy drinks without the unpleasant sensory feeling is boosting research for a clearer understanding on the interactions
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