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Merck
CN

03-0146-00

SMC® 淀粉样β42高灵敏度试剂盒

Used for ultrasensitive quantification of Amyloid Beta 1-42 (Aβ42) in human, rat or mouse plasma or cerebrospinal fluid (CSF)

别名:

Abeta 1-42 immunoassay kit, Abeta 42 Single Molecule Counting Kit, Abeta 42 immunoassay kit, Abeta 42 ultra-sensitive Immunoassay

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关于此项目

NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with for use with FemtoQuest and SMCxPRO® instruments (validated)
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Quality Level

technique(s)

single molecule counting: suitable

input

serum
plasma
cerebrospinal fluid (CSF)

compatibility

for use with for use with FemtoQuest and SMCxPRO® instruments (validated)

shipped in

wet ice

storage temp.

2-8°C

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

human

General description

SMC® 淀粉样蛋白 β 1-42 高灵敏度免疫检测试剂盒包含进行测定所需的所有试剂。该测定采用标准免疫测定工作流程,配置标准板形式。

测定方案与现有的夹心 ELISA 方法相似,但有两个主要区别:
1)洗脱缓冲液破坏三明治,分离标记的检测抗体用于进行定量。
2)Erenna 和 SMCxPRO® 免疫测定系统使用单分子计数(SMC®)技术检测分析物。

Application

Neuroscience/Neurological Disorders/Signaling

Features and Benefits

  • High Sensitivity Detection: Precisely quantifies Amyloid Beta 1-42 at femtogram/mL levels in plasma or CSF.
  • Improved Dynamic Range: Enhanced signal-to-noise ratio with reduced background interference for reliable assay performance.
  • User-Friendly Workflow: Utilizes a familiar sandwich immunoassay format while ensuring high sensitivity for Aβ1-42 detection.
  • Automation-Ready: Compatible with automated liquid handling systems, reducing manual steps and increasing lab efficiency.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 980 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 244-250,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: CSF: 100%
  • Recovery: Plasma: 94% CSF: 92%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although Amyloid Beta 42 was detectable in mouse and rat samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

target_organs

Respiratory Tract

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation

法规信息

含少量动物源组分生物产品
常规特殊物品
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分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

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Journal of clinical medicine, 8(10) (2019-10-09)
Nondemented people with a family history of Alzheimer's disease (ADFH) and the ApoE-4 allele have been demonstrated to show a trend for a higher probability of cognitive decline and aberrant levels of cognitive-related biomarkers. However, the potential interactive effects on

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