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Merck
CN

HCMP2MAG-19K

MILLIPLEX® 人补体板2 - 免疫学多重检测

Configurable Human Complement 6-Plex Panel 2

别名:

Human complement multiplex kit, Luminex® human complement immunoassay, Millipore human complement panel

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关于此项目

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
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产品名称

MILLIPLEX® 人补体板2 - 免疫学多重检测, Configurable Human Complement 6-Plex Panel 2

species reactivity

human

manufacturer/tradename

Milliplex®

Quality Level

packaging

1 ea of

assay range

accuracy: 95%
(Complement C3)

sensitivity: 0.024 ng/mL
(Complement Factor B)

sensitivity: 0.048 ng/mL
(Complement C1q)

sensitivity: 0.120 ng/mL
(Complement C3)

sensitivity: 0.135 ng/mL
(Complement Factor H)

sensitivity: 0.191 ng/mL
(Complement C4)

sensitivity: 3.639 ng/mL
(Complement C3b/iC3b)

standard curve range: 0.041-300 ng/mL
(Complement Factor H)

standard curve range: 0.08-60 ng/mL
(Complement C1q)

standard curve range: 0.08-60 ng/mL
(Complement Factor B)

standard curve range: 0.27-200 ng/mL
(Complement C3)

standard curve range: 0.55-400 pg/mL
(Complement C4)

technique(s)

multiplexing: suitable

input

serum plasma (Cell culture, cell culture supernatants)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

ambient
wet ice

storage temp.

2-8°C

Preparation Note

试剂盒组分建议的存储温度为2-8°C。

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Biochem/physiol Actions

交叉反应性
抗体与该面板中任何其他分析物之间的交叉反应性都为无法检测或可忽略。

Features and Benefits

通过在此面板中选择可用的分析物来设计多重试剂盒。

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

General description

The complement system consists of a large number of plasma proteins that assist, or complement, the ability of phagocytic cells and antibodies to clear pathogens. Although it is part of the innate immune system, not adaptable and unchanging over the course of a lifetime, it can be recruited and activated by the adaptive immune system. The system proteins and glycoproteins that are synthesized primarily by hepatocytes normally circulate as inactive pro-proteins. Once stimulated the end result of the cascade is a massive amplification of response and activation of the membrane attack complex, which forms a transmembrane pore causing osmotic lysis of target cells. The complement system consists of three different simultaneous pathways. The classical pathway is stimulated by antigen-antibody complexes; the alternative pathway spontaneously activates on contact with pathogenic cell surfaces; the mannose-binding lectin pathway recognizes mannose sugars usually present only on pathogenic cell surfaces. The complement system is thought to play a key role in many diseases with an immune component, such as asthma or sepsis, and in many autoimmune diseases, including systemic lupus erythematosus, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis. It is also becoming increasingly associated with neurological diseases, such as Alzheimer′s Disease, and conditions such as spinal cord injuries.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in human serum, plasma, and cell culture supernatants.

Analytes included: C1q, C3, C3b, C4, Factor B, Factor H

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

存储类别

10 - Combustible liquids

wgk

WGK 3

法规信息

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Laura McCulloch et al.
F1000Research, 8, 1039-1039 (2019-11-12)
Background: Blockade of the cytokine interleukin-1 (IL-1) with IL-1 receptor antagonist (IL-1Ra) is a candidate treatment for stroke entering phase II/III trials, which acts by inhibiting harmful inflammatory responses.  Infection is a common complication after stroke that significantly worsens outcome
Manjunath Ramanjaneya et al.
Frontiers in endocrinology, 13, 918320-918320 (2022-08-02)
Complement factors mediate the recruitment and activation of immune cells and are associated with metabolic changes during pregnancy. The aim of this study was to determine whether complement factors in the maternal serum and follicular fluid (FF) are associated with
Shamma Al-Muraikhy et al.
Frontiers in molecular biosciences, 8, 715035-715035 (2021-10-12)
Introduction: Aerobic exercise activates the complement system in the peripheral blood. However, the effect of age and high intensity endurance training on the levels of circulating complements and sassociated inflammatory cytokines, oxidative stress markers and cellular aging remains unknown. Methods:
Pavan Bhargava et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 27(4), 509-518 (2020-07-17)
Synaptic loss is a feature of multiple sclerosis pathology that can be seen even in normal-appearing gray matter. Opsonization of synapses with complement components may underlie pathologic synapse loss. We sought to determine whether circulating neuronal-enriched and astrocytic-enriched extracellular vesicles
Manjunath Ramanjaneya et al.
Frontiers in endocrinology, 12, 740703-740703 (2022-03-08)
The complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity. Complement-related protein activation occurs through three distinct pathways: classical, alternative, and lectin-dependent pathways, which are regulated by cascades of multiple proteins.

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MILLIPLEX® multiplex assays provide a comprehensive catalog of biomarkers, offering unique analytes not available from other Luminex® assay suppliers.

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