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Merck
CN

85558

精脒

BioUltra, Molecular Biology, ≥99.5% (GC)

别名:

SPD, 1,8-二氨基-4-氮杂辛烷, N-(3-氨基丙基)-1,4-丁烷

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关于此项目

线性分子式:
NH2(CH2)3NH(CH2)4NH2
化学文摘社编号:
分子量:
145.25
UNSPSC Code:
12352116
NACRES:
NA.26
PubChem Substance ID:
EC Number:
204-689-0
Beilstein/REAXYS Number:
1698591
MDL number:
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产品名称

精脒, BioUltra, Molecular Biology, ≥99.5% (GC)

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

SMILES string

NCCCCNCCCN

grade

Molecular Biology

product line

BioUltra

assay

≥99.5% (GC)

storage condition

(Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)

technique(s)

ChIP: suitable
buffer exchange: suitable

impurities

DNases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected

refractive index

n20/D 1.479 (lit.)

pH

12.0-13.5 (25 °C, 1 M in H2O)

solubility

H2O: 1 M at 20 °C, clear, colorless

density

0.925 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.05

suitability

suitable for molecular biology

application(s)

advanced drug delivery
genomic analysis

Quality Level

Gene Information

rat ... Ppm1a(24666)

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Analysis Note

液体或固体

Application

亚精胺可作为:
  • 染色体分离缓冲液成分
  • 转录缓冲液成分
  • 均质化缓冲液成分

Biochem/physiol Actions

亚精胺能调节各种细胞活动,如调节细胞生长发育、DNA稳定性和细胞凋亡。
抑制神经元型一氧化氮合成酶(nNOS)。结合和沉淀DNA,可用于DNA结合蛋白纯化。激活T4聚核苷酸激酶活性。
抑制神经元型一氧化氮合成酶(nNOS)。结合和沉淀DNA;激活T4聚核苷酸激酶活性。

Disclaimer

如果需要无菌溶液,则应采用无菌过滤而非高压灭菌。时间一长,亚精胺将发生脱氨基作用;溶液应采用冷冻保存。通常需要配制新溶液。

Features and Benefits

  • 它用途广泛,适用于各种实验室和研究应用环境
  • 适用于分子生物学和生物化学研究
  • 不含 DNase, RNase, NICKase, 和 蛋白酶
  • 经检验测定重金属污染水平低,确保适用于各种应用
  • 经检测含有痕量阴离子和阳离子

General description

亚精胺是一种多胺 和三价有机阳离子。亚精胺是一种天然存在的多胺化合物,具有多种生物性能它在基因表达中发挥着重要的作用,它参与DNA复制、转录和翻译过程。亚精胺对于细胞生长、增殖和分化非常重要,它影响细胞周期进程和组织发育。它具有抗氧化活性,通过清除自由基来保护细胞免受氧化应激。亚精胺还刺激细胞自噬,促进受损细胞器周转和蛋白质聚集,从而实现细胞稳态。它具有神经保护作用,支持神经元存活、突触可塑性,并预防神经退行性疾病。此外,亚精胺还可调节参与炎症和免疫反应的细胞信号通路。

Other Notes

在第一链 cDNA 合成中 ;琼脂糖污染物对核酸内切酶抑制的影响
如需了解生化试剂系列的更多信息,请填写此表

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

存储类别

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

233.6 °F - closed cup

flash_point_c

112 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is this a spermidine solution or a neat liquid, and what is the concentration?

    Based on a density of 0.925 g/mL and a molecular weight of 145.25, this neat liquid has an effective molarity of 6.4 M.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 231-247 (2016)
Krug, M.S. et al.
Methods in Enzymology, 152, 321-321 (1987)
Sample Preparation of Telomerase Subunits for Crystallization
Huang J, et al.
Bio-protocol, 5(16) (2015)
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Beaton-GLA, et al.
Methods, 18-24 (2017)

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