HPA002807
Anti-MFGE8 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
MFG-E8 Antibody - Anti-MFGE8 antibody produced in rabbit, Mfg-E8 Antibody, Anti-Breast epithelial antigen BA46 antibody produced in rabbit, Anti-HMFG antibody produced in rabbit, Anti-Lactadherin precursor antibody produced in rabbit, Anti-MFG-E8 antibody produced in rabbit, Anti-MFGM antibody produced in rabbit, Anti-Milk fat globule-EGF factor 8 antibody produced in rabbit
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关于此项目
Human Protein Atlas Number:
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC
Citations:
12
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
orthogonal RNAseq
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:500-1:1000
immunogen sequence
LKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLEL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MFGE8(4240)
General description
MFGE8 (milk fat globule-EGF factor 8 protein) is a ~53kDa plasma membrane glycoprotein that is generated at the bud from the apical surface of mammary epithelial cells during lactation. It is composed of two specific functional domains: an N-terminal domain with two epidermal growth factor (EGF) repeats and a C-terminal domain with two Discoidin/F5/8C domains for binding of anionic phospholipids and/or extracellular matrices.
MFGE8 is mapped to human chromosome 15q26.1.
Immunogen
Lactadherin precursor recombinant protein epitope signature tag (PrEST)
Application
Anti-MFGE8 antibody produced in rabbit has been used in immunofluorescence.
Anti-MFGE8 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem/physiol Actions
MFGE8 (milk fat globule-EGF factor 8) protein is involved in wide range of cellular interactions such as phagocytosis of apoptotic lymphocytes and other apoptotic cells, cell adhesion of sperm and the egg coat, intestinal mucosa repair, mammary gland branching morphogenesis, angiogenesis etc. It is potentially involved in different stages of sperm maturation and fertilization mechanism. It accelerates the engulfment of apoptotic carcinoma cells by living carcinoma cells which in turn promotes tumor growth.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Other Notes
Corresponding Antigen APREST77458
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Timothy A Reinhardt et al.
Journal of proteomics, 82, 141-154 (2013-03-06)
Milk protein expression in healthy cows and cows with mastitis will provide information important for the dairy food industry and immune function in the mammary gland. To facilitate protein discovery, milk was fractioned into whey, milk fat globule membranes (MFGM)
Benedikt Kirchner et al.
PloS one, 15(2), e0229606-e0229606 (2020-02-29)
Extracellular vesicles (EVs) such as exosomes are key regulators of intercellular communication that can be found in almost all bio fluids. Although studies in the last decade have made great headway in discerning the role of EVs in many physiological
Manabu Yamazaki et al.
Laboratory investigation; a journal of technical methods and pathology, 94(11), 1260-1272 (2014-09-30)
Milk fat globule--epidermal growth factor (EGF)--factor VIII (MFG-E8) is a secreted glycoprotein that promotes clearance of apoptotic cells by bridging phosphatidylserine on apoptotic cells and integrin αvβ3/5 on phagocytes. High expression of MFG-E8 has been reported in various types of
Mutation Identification for Epilepsy in the US Hispanic Population Using Whole-Exome-Sequencing
Villanos M, et al.
Journal of Cell Biology and Cell Metabolism, 3(011) (2016)
Mara D Saenz-de-Juano et al.
BMC genomics, 23(1), 189-189 (2022-03-09)
Subclinical mastitis, the inflammation of the mammary gland lacking clinical symptoms, is one of the most prevalent and costly diseases in dairy farming worldwide. Milk microRNAs (miRNAs) encapsulated in extracellular vesicles (EVs) have been proposed as potential biomarkers of different
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