Merck
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文件

LO3300

Sigma-Aldrich

LOPAC®1280 (International Version)

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别名:
Library of Pharmacologically Active Compounds
NACRES:
NA.77

形式

liquid

质量水平

100

运输

dry ice

储存温度

−20°C

一般描述

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (250 μl at 10 mM in DMSO in archival storage racks).

应用

LOPAC®1280 (International Version) has been used to screen chemical inhibitors with dephosphorylation activity. It has also been used in MyoScreen myotubes to screen for muscle regeneration molecules.

特点和优势

Collection of approximately 1,280 pharmacologically active Sigma compounds.
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apotosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:

  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Sigma-RBI Product Number (for easy re-order)
  • Rack Position

其他说明

For sale outside of the U.S. only. U.S. customers should refer to Product Code LO1280.

法律信息

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

188.6 °F - closed cup

闪点(°C)

87 °C - closed cup

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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在网站页面上，产品编号会附带包装尺寸/数量一起显示（例如：T1503-25G）。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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批号可以在产品标签上"批“ （Lot或Batch）字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。

  • 如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。

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未找到您寻找的产品？

部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。

索取COA

Temperature-sensitive substrate and product binding underlie temperature-compensated phosphorylation in the clock
Shinohara Y, et al.
Molecular Cell, 67(5), 783-798 (2017)
MyoScreen, a High-Throughput Phenotypic Screening Platform Enabling Muscle Drug Discovery
Young J, et al.
SLAS discovery, 23(8), 790-806 (2018)
Jaime Freitas et al.
Current chemical genomics and translational medicine, 8, 36-46 (2014-04-29)
To adapt the use of GH3.TRE-Luc reporter gene cell line for a quantitative high-throughput screening (qHTS) platform, we miniaturized the reporter gene assay to a 1536-well plate format. 1280 chemicals from the Library of Pharmacologically Active Compounds (LOPAC) and the
Linda Rickardson et al.
Journal of biomolecular screening, 12(2), 203-210 (2007-01-09)
The proteasome is a new, interesting target in cancer drug therapy, and the proteasome inhibitor bortezomib has shown an effect in myeloma patients. It is of interest to efficiently discover and evaluate new proteasome inhibitors. The authors describe the development
Houtan Moshiri et al.
Journal of biomolecular screening, 20(1), 92-100 (2014-08-30)
Most mitochondrial messenger RNAs in trypanosomatid pathogens undergo a unique type of posttranscriptional modification involving insertion and/or deletion of uridylates. This process, RNA editing, is catalyzed by a multiprotein complex (~1.6 MDa), the editosome. Knockdown of core editosome proteins compromises
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Compound Library Screening with LOPAC®1280 Small Molecules

Learn about compound library screening and explore our compound libraries, including our Library of Pharmacologically Active Compounds (LOPAC®1280) portfolio to experience the gold-standard collection of biologically annotated, ready-to-screen compounds.

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