M0317
Microsomes from Liver, Pooled
from human
Synonym(s):
Liver Microsomes
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About This Item
NACRES:
NA.47
UNSPSC Code:
12161501
Application
Microsomes from liver have been used to study the in vitro effect of Clinacanthus nutans leaves on the activity of cytochrome P450 3A4 and 2E1.
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Source of drug metabolizing enzymes, including cytochrome P-450.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Related Content
Datasheet
Britta Heinze et al.
European journal of nuclear medicine and molecular imaging, 49(1), 301-310 (2021-07-04)
Adrenal tumors represent a diagnostic and therapeutic challenge. Promising results have been obtained through targeting the cytochrome P450 enzymes CYP11B1 and CYP11B2 for molecular imaging, and [123/131I]iodometomidate ([123/131I]IMTO) has even been successfully introduced as a theranostic agent. As this radiopharmaceutical
Verawan Uchaipichat
Drug metabolism and pharmacokinetics, 33(1), 67-76 (2017-12-16)
This study aimed to investigate the liver microsomal inhibitory effects of silybin, silychristin, andrographolide, and curcumin by using morphine as an in vitro UGT2B7 probe substrate, and predict the magnitude of the herb-drug interaction arising from these herbal constituents' inhibition in vivo.
Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans
Sukh Yen Khua
Drug metabolism and personalized therapy (2017)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M0317-1VL | 04061833992999 |