M0567
Microsomes from Liver, Pooled
from human male
Synonym(s):
lab equipment accessory
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About This Item
NACRES:
NA.54
UNSPSC Code:
12352204
Product Name
Microsomes from Liver, Pooled, from human male
biological source
human male
form
liquid
packaging
vial of ~10 mg
shipped in
dry ice
storage temp.
−70°C
Quality Level
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Application
Microsomes from Liver, Pooled has been used:
- in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
- as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
- to study the metabolization of enantiomeric peptide D3
Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.
Source of drug metabolizing enzymes, including cytochrome P-450.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Mohamed W Attwa et al.
Drug design, development and therapy, 14, 4439-4449 (2020-10-31)
Tandutinib (MLN518 or CT 53518) (TND) is a novel, oral, small-molecule inhibitor of type III receptor tyrosine kinases utilized for the treatment of acute myeloid leukemia (AML). In silico prediction of hepatic drug metabolism for TND was determined using the
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
T OMURA et al.
The Journal of biological chemistry, 239, 2370-2378 (1964-07-01)
Sarvesh C Vashishtha et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(10), 1070-1076 (2002-09-14)
N-Glucuronidation at an aromatic tertiary amine of 5-membered polyaza ring systems was investigated for a model series of eight 1-substituted imidazoles in liver microsomes from five species. The major objectives were to investigate substrate specificities of the series in human
The Carbon Monoxide-binding pigment of liver microsomes II. Solubilization, purification and properties.
Omura, T. and Sato, R.
Journal of Biochemistry, 239, 2379-2385 (1964)
Mohamed W Attwa et al.
Drug design, development and therapy, 14, 783-793 (2020-03-12)
Talazoparib (BMN673) is a new poly(ADP-ribose) polymerase inhibitor that has been FDA approved for patients suffering from metastatic breast cancer with germline BRCA mutations. In the current study, an accurate and efficient liquid chromatography-tandem mass spectrometry (LC-MS/MS) analytical methodology was
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