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M0567

Microsomes from Liver, Pooled

from human male

Synonym(s):

lab equipment accessory

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About This Item

NACRES:
NA.54
UNSPSC Code:
12352204
Biological source:
human male
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biological source

human male

Quality Segment

form

liquid

packaging

vial of ~10 mg

shipped in

dry ice

storage temp.

−70°C

Application

Microsomes from Liver, Pooled has been used:
  • in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
  • as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
  • to study the metabolization of enantiomeric peptide D3

Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.

Biochem/physiol Actions

N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Source of drug metabolizing enzymes, including cytochrome P-450.

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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