M6133
5′-三磷酸 7-甲基鸟苷 钠盐
≥85% (HPLC), natural (inorganic), powder
别名:
m7GTP
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关于此项目
经验公式（希尔记法）:
C11H18N5O14P3 · xNa+
化学文摘社编号:
分子量:
537.21 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
产品名称
5′-三磷酸 7-甲基鸟苷 钠盐, ≥85% (HPLC)
SMILES string
[Na+].C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]2O)c3N=C(N)NC([O-])c13
InChI
1S/C11H20N5O14P3.Na/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22;/h3-4,6-7,9-10,17-18H,2H2,1H3,(H,23,24)(H,25,26)(H3,12,13,14)(H2,20,21,22);/q;+1/p-1/t4-,6-,7-,9?,10-;/m1./s1
InChI key
FSMRTZAMTMQMEF-OCMBMSOASA-M
biological source
natural (inorganic)
assay
≥85% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to faint yellow or tan
storage temp.
−20°C
Quality Level
Application
7-甲基鸟苷5′-三磷酸盐 (m7GTP) 被用来在 mRNA 参与蛋白质合成的背景下研究真核细胞 mRNA 帽的结构和机制。m7GTP 可用于产生捕获和纯化分子（如真核起始因子 eIF4E）的亲和介质。
7-甲基鸟苷5′-三磷酸钠盐已被用于通过荧光滴定法测试其对多聚（A）特异性核糖核酸酶（PARN）多肽的亲和力。它也与gemin5片段（G5N）和人La相关15蛋白1（LARP1）的DM15区一起用于结晶。
Biochem/physiol Actions
7-M甲基鸟苷 5′-三磷酸盐 (m7GTP) 通过结合翻译起始复合物抑制体外蛋白质合成。m7GTP用于在mRNA参与蛋白质合成的背景下研究真核细胞mRNA帽的结构和机制。m7GTP对真核起始因子eIF4E有很高的亲和力并可用于产生捕获和纯化起始因子的亲和介质。
General description
7-甲基鸟苷5-′三磷酸是mRNA帽结构类似物。
Alan L Ho et al.
PloS one, 7(7), e40439-e40439 (2012-07-19)
Uveal melanomas possess activation of the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT/mammalian Target of Rapamycin (mTOR) pathways. MAPK activation occurs via somatic mutations in the heterotrimeric G protein subunits GNAQ and GNA11 for over 70% of tumors and
Susan Parrish et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(7), 2139-2144 (2007-02-07)
Previous studies indicated that the vaccinia virus D10 protein, which is conserved in all sequenced poxviruses, participates in the rapid turnover of host and viral mRNAs. D10 contains a motif present in the family of Nudix/MutT enzymes, a subset of
The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA
Soto-Rifo R, et al.
Nucleic Acids Research, 41(12), 6286-6299 (2013)
A multifunctional RNA recognition motif in poly (A)-specific ribonuclease with cap and poly (A) binding properties
Nilsson P, et al.
The Journal of biological chemistry, 282(45), 32902-32911 (2007)
Regina Cencic et al.
Analytical biochemistry, 560, 24-29 (2018-09-09)
All cellular cytoplasmic mRNAs are capped at their 5' ends with an m7GpppN group. Several proteins that mediate cap function have been identified by cap affinity purification, enabling their characterization in a number of biological processes. Among these, eukaryotic initiation
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