Biochem/physiol Actions
肝微粒体是来源于肝细胞内质网的亚细胞颗粒。这些微粒体是药物代谢酶（包括细胞色素 P-450）的丰富来源。不同来源的微粒体池有助于研究外源代谢和药物相互作用。
药物代谢酶的来源，包括细胞色素 P-450。
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.
Application
Microsomes from Liver, Pooled has been used in following studies:
- inhibition of microsomal lipid peroxidation.
- hydroxylation of isorhynchophylline (ISOR) in rats.
General description
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
此项目有
Xiaofei Zhang et al.
ACS chemical neuroscience, 8(9), 1937-1948 (2017-06-02)
Metabotropic glutamate 2 receptors (mGlu
Metabolism of isorhynchophylline in rats detected by LC-MS.
Wang W
J. Pharm. Pharm. Sci., 13(1), 27-37 (2010)
Paloma Begines et al.
Journal of agricultural and food chemistry, 67(26), 7281-7288 (2019-06-15)
Potential metabolites of bioactive compounds are important for their biological activities and as authentic standards for metabolic studies. The phenolic compounds contained in olive oil are an important part of the human diet, and therefore their potential metabolites are of
Metabolism of small antimicrobial ?(2,2)-amino acid derivatives by murine liver microsomes.
Hansen T
Eur. J. Drug Metab. Pharmacokinet., 37(3), 191-201 (2012)
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes.
Lu AY and Coon MJ
The Journal of Biological Chemistry, 243(6), 1331-1332 (1968)
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