M9066
Microsomes from Liver, Pooled
from rat(Sprague-Dawley), male
Synonym(s):
Liver microsome preparation
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About This Item
NACRES:
NA.47
UNSPSC Code:
12161501
biological source
rat (Sprague-Dawley)
form
liquid
packaging
vial of ~10 mg
shipped in
dry ice
storage temp.
−70°C
Quality Level
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General description
Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).
Application
Microsomes from Liver, Pooled has been used in following studies:
- inhibition of microsomal lipid peroxidation.
- hydroxylation of isorhynchophylline (ISOR) in rats.
Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives.
Source of drug metabolizing enzymes, including cytochrome P-450.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
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Xiaofei Zhang et al.
ACS chemical neuroscience, 8(9), 1937-1948 (2017-06-02)
Metabotropic glutamate 2 receptors (mGlu
Metabolism of isorhynchophylline in rats detected by LC-MS.
Wang W
J. Pharm. Pharm. Sci., 13(1), 27-37 (2010)
Isoquercitrin Esters with Mono- or Dicarboxylic Acids: Enzymatic Preparation and Properties.
Vavrikova E
International Journal of Molecular Sciences, 17(6) (2016)
Gengyang Yuan et al.
Journal of medicinal chemistry, 63(20), 12060-12072 (2020-09-29)
Three benzimidazole derivatives (13-15) have been synthetized as potential positron emission tomography (PET) imaging ligands for mGluR2 in the brain. Of these compounds, 13 exhibits potent binding affinity (IC50 = 7.6 ± 0.9 nM), positive allosteric modulator (PAM) activity (EC50
Liver microsomes; an integrated morphological and biochemical study.
PALADE GE
The Journal of Biophysical and Biochemical Cytology, 2(2), 171-200 (1956)
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