产品名称
来自肝脏的微粒体,合并, from mouse(CD-1), male
biological source
mouse (CD-1)
form
liquid
packaging
vial of ~10 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
mouse ... Mgst1(56615)
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Application
合并的肝脏微粒体也已用于研究抗肿瘤药物和衣霉素的代谢稳定性。
合并的肝脏微粒体已用于大肠埃希菌的细胞存活和突变测定。
Biochem/physiol Actions
微粒体可能充当细胞器,并积极参与蛋白合成。微粒体的一氧化碳结合色素,称为P-450,是混合功能氧化酶系统的组成部分,参与药物和类固醇的氧化去甲基化和羟基化。鼠肝微粒体在降解小的抗菌β2,2-氨基酸衍生物中起着至关重要的作用。
肝微粒体是来源于肝细胞内质网的亚细胞颗粒。这些微粒体是药物代谢酶(包括细胞色素 P-450)的丰富来源。不同来源的微粒体池有助于研究外源代谢和药物相互作用。
药物代谢酶的来源,包括细胞色素 P-450。
General description
微粒体是从肝脏和其他组织匀浆中分离出的“亚显微”颗粒部分。微粒体富含核糖核酸(RNA)。
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
Structures of DPAGT1 explain glycosylation disease mechanisms and advance TB antibiotic design
Dong YY, et al.
Cell, 175(4), 1045-1058 (2018)
AQ-4, a deuterium-containing molecule, acts as a microtubule-targeting agent for cancer treatment
Lin BY, et al.
European Journal of Pharmacology, 173093-173093 (2020)
Metabolism of small antimicrobial ?(2,2)-amino acid derivatives by murine liver microsomes.
Hansen T
Eur. J. Drug Metab. Pharmacokinet., 37(3), 191-201 (2012)
Mikhail Krasavin et al.
European journal of medicinal chemistry, 127, 357-368 (2017-01-12)
A series of spirocyclic compounds inspired by Eli Lilly's phase 1 antidiabetic FFA1 receptor agonist LY2881835 was designed to include polar aromatic periphery groups and explore a possibility of building additional contacts with the target near the agonist binding site.
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes.
Lu AY and Coon MJ
The Journal of Biological Chemistry, 243(6), 1331-1332 (1968)
相关内容
Instructions
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