PRS2501
Anti-CIKS antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-TRAF3 Interacting protein 2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 63 kDa
species reactivity
human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TRAF3IP2(10758)
General description
CIKS (connection to IKK (IκB kinase) and SAPK (stress-activated protein kinase) /JNK (jun kinase)) is a cytoplasmic protein, that exists in the nucleus. It is also termed as Act1(NF-κB activator 1) and TRAF3IP2 (TRAF3 interacting protein 2). It is located on chromosome 6q21.
Immunogen
a synthetic peptide corresponding to amino acids 2-15 of human CIKS.
Biochem/physiol Actions
CIKS (connection to IKK (IκB kinase) and SAPK (stress-activated protein kinase) /JNK (jun kinase)) is susceptible to various diseases like psoriasis and psoriatic arthritis. It is responsible for the cardiomyocyte growth, fibroblast migration and proliferation, promoted by aldosterone. It participates in the signaling function of IL-17 (interleukin) cytokine family. It can act as a transcriptional enhancer due to its presence in the nuclear compartment of airway epithelial cells.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP2501.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1
Velichko S, et al.
PLoS ONE, 11(10) (2016)
Identification of alternatively spliced Act1 and implications for its roles in oncogenesis
Xia YF, et al.
Biochemical and Biophysical Research Communications, 296(2), 406-412 (2002)
A pharmacogenetics study in Mozambican patients treated with nevirapine: full resequencing of TRAF3IP2 gene shows a novel association with SJS/TEN susceptibility
Ciccacci C, et al.
International Journal of Molecular Sciences, 16(3), 5830-5838 (2015)
Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2
Somanna NK, et al.
Cellular Signalling, 27(10), 1928-1938 (2015)
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