PRS3197
Anti-Caspase-12 (small) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Caspase 12
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 46 kDa
species reactivity
mouse, human, rat
technique(s)
immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Casp12(12364)
General description
Caspase-12 (CASP12) is an immunomodulatory factor, that is present in the cytoplasmic side of the ER (endoplasmic reticulum). It is upregulated highly in muscle, liver and kidney.
Immunogen
a synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12.
Biochem/physiol Actions
Caspase-12 (CASP12) plays an important role in endoplasmic reticulum (ER)-related apoptosis. It moderates hepatocyte apoptosis prompted by carbon tetrachloride. Lack of caspase-12 (CASP12) increases cytokine responses.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3197.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro
Liu LQ, et al.
Alcoholism, Clinical and Experimental Research, 38(3), 683-693 (2014)
Caspase-12 deficiency enhances cytokine responses but does not protect against lethal Plasmodium yoelii 17XL infection
Miu J, et al.
Parasite Immunology, 32(11-12), 773-778 (2010)
Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice
Liu H, et al.
World Journal of Gastroenterology, 20(48), 18189-18198 (2014)
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance
Skeldon AM, et al.
Journal of Immunology, 196(1), 437-447 (2016)
Juan Carlos Gómora-García et al.
Cell death discovery, 7(1), 131-131 (2021-06-05)
Altered protein homeostasis is associated with neurodegenerative diseases and acute brain injury induced under energy depletion conditions such as ischemia. The accumulation of damaged or unfolded proteins triggers the unfolded protein response (UPR), which can act as a homeostatic response
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