产品名称
抗-ST2 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Il1rl1(17082)
Application
抗-ST2已被用于免疫组化、蛋白质印迹和免疫荧光染色。
Biochem/physiol Actions
ST2（致瘤性抑制）参与哮喘、关节炎、肥胖、动脉粥样硬化等多种疾病的病理生理。它在嗜酸性粒细胞、纤维细胞、内皮细胞中起丝裂原的作用。它有助于Th2淋巴细胞、纤维细胞和内皮细胞的迁移，并可干扰乳腺肿瘤的侵袭和转移。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
General description
ST2（致癌抑制因子）属于细胞因子IL-1家族。它也称为 IL-33（白细胞介素33）和IL1RL1（白细胞介素1受体样1）。它在巨噬细胞和各种炎症细胞（如辅助性T细胞2（Th2））、肥大细胞、嗜碱细胞和嗜酸粒细胞中表达。它位于染色体2q12。
Immunogen
与小鼠ST2氨基末端16个氨基酸对应的合成肽。该肽序列在三种已知的ST2同种型中共有。
Other Notes
可以使用阻断肽 SBP3363 阻断该抗体的作用。
Physical form
溶剂为含有0.02％叠氮化钠的磷酸盐缓冲盐水
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
IL?33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrin ?4?1 and CD62L
Wang XH, et al.
Molecular Medicine Reports, 16(4), 3887-3893 (2017)
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
Sedhom MA, et al.
Gut, 62(12), 1714-1723 (2013)
The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
Mertz KD, et al.
Oncoimmunology, 5(1) (2015)
ST2L Transmembrane Receptor Expression: An Immunochemical Study on Endarterectomy Samples
Marzullo A, et al.
PLoS ONE, 11(5) (2016)
Wen-Ting Hu et al.
Molecular human reproduction, 20(4), 358-372 (2013-12-18)
Interleukin (IL)-33, a newly described member of the IL-1 family, has been reported to facilitate primary tumor progression and metastatic dissemination. However, its biological function on decidual stromal cells (DSCs) remains unclear. In this study, we tested the hypothesis whether
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