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SAB3500051

Anti-SHOC2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Leucine-rich repeat protein SHOC-2, Anti-Ras-binding protein Sur-8, Anti-SOC2

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, WB
Citations:
3

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

NP_031399

UniProt accession no.

Q9UQ13

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SHOC2(8036)

Related Categories

General description

Leucine-rich repeat protein SHOC-2 is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and is cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade.

Immunogen

SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.

Biochem/physiol Actions

Leucine-rich repeat protein SHOC2 participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. SHOC2, together with protein phosphatase 1c (PP1c), forms a highly specific M-Ras effector complex and is essential for the activation of MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.

Features and Benefits

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Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500051.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
52150903

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soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling
Laura M
Proceedings of the National Academy of Sciences of the USA, 95(12), 6903-6908 (1998)
Mutation in SHOC2 promotes aberrant protein N-myristoylation and underlies Noonan-like syndrome with loose anagen hair
Viviana Cordeddu
Nature Genetics, 41(9), 1022-1026 (2009)
Noonan syndrome-like disorder with loose anagen hair: a second case with neuroblastoma.
Garavelli L
American Journal of Medical Genetics. Part A, 167A(8), 1902-1907 (2015)

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