SAB3500051
Anti-SHOC2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Leucine-rich repeat protein SHOC-2, Anti-Ras-binding protein Sur-8, Anti-SOC2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
indirect ELISA
western blot
indirect ELISA
western blot
Species reactivity:
rat, mouse, human
Citations:
3
Technique(s):
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-SHOC2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SHOC2(8036)
Biochem/physiol Actions
Leucine-rich repeat protein SHOC2 participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. SHOC2, together with protein phosphatase 1c (PP1c), forms a highly specific M-Ras effector complex and is essential for the activation of MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.
Features and Benefits
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General description
Leucine-rich repeat protein SHOC-2 is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and is cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade.
Immunogen
SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500051.
Physical form
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Mutation in SHOC2 promotes aberrant protein N-myristoylation and underlies Noonan-like syndrome with loose anagen hair
Viviana Cordeddu
Nature Genetics, 41(9), 1022-1026 (2009)
soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling
Laura M
Proceedings of the National Academy of Sciences of the USA, 95(12), 6903-6908 (1998)
Noonan syndrome-like disorder with loose anagen hair: a second case with neuroblastoma.
Garavelli L
American Journal of Medical Genetics. Part A, 167A(8), 1902-1907 (2015)
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