Anti-SYPL1 antibody produced in rabbit

The synaptophysin-like protein 1, also known as pantophysin, is a homolog of the neuroendocrine-specific protein synaptophysin, with the highest level of homology across its four transmembrane domains. Unlike synaptophysin however, SYPL1 is ubiquitously expressed and found in small cytoplasmic transport vesicles regardless of their content. SYPL1 is thought to play a multifunctional role in vesicle biogenesis and transport and is a component of adipocyte transport vesicles, and thus may be involved in adipocyte secretion. SYPL1 also interacts with vesicle-associated membrane protein 2 (VAMP-2) in adipocytes and associates with GLUT4-containing vesicles. This antibody will not recognize synaptophysin of SYPL2. Two isoforms of SYPL1 are known to exist; this antibody will only recognize the longer isoform.

SYPL1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human SYPL1.

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Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

The action of this antibody can be blocked using blocking peptide SBP3500080.