生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
分子量
49 kDa
种属反应性
human, mouse
浓度
1 mg/mL
技术
ELISA: suitable
immunocytochemistry: suitable
western blot: suitable
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TRMT12(55039)
一般描述
TRMT12 (tRNA methyltransferase 12 homolog) gene is localized to human chromosome 8q24, and is a homolog of yeast gene coding for a tRNA methyltransferase.
免疫原
Antibody was raised against a 19 amino acid peptide near the amino terminus of human TYW2.
生化/生理作用
TRMT12 (tRNA methyltransferase 12 homolog) gene is amplified and over-expressed in breast cancer. This enzyme is responsible for catalyzing the third step in wybutosine biosynthetic pathway. In cancer, up-regulation of this gene leads to disruption in SMG1 protein function, which is a part of nonsense mediated decay pathway (NMD). Thus, it might contribute to the escape of damaged DNA from checkpoints.
特点和优势
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联系
The action of this antibody can be blocked using blocking peptide SBP3500666.
外形
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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