SAB3500952
Anti-IL-37 antibody produced in rabbit
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 24 kDa
species reactivity
human
concentration
1 mg/mL
technique(s)
ELISA: suitable, immunoblotting: suitable, immunofluorescence: suitable, immunohistochemistry: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... IL37(27178)
General description
IL-37 (interleukin 37) is an anti-inflammatory cytokine and is also termed as IL-1 family member 7 (IL-1F7). IL-37 belongs to the IL-1 cytokine family. This protein is expressed in blood monocytes, endothelial cells, adipocytes and epithelial cells. IL-37 is located on human chromosome 2q12.
Immunogen
Antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.
Biochem/physiol Actions
IL-37 (interleukin 37) acts as a suppressor for innate immunity and acquired immunity. IL-37 participates in the immunosuppressive property of human CD4+CD25+ regulatory T cells. It represses the synthesis of several pro-inflammatory cytokines like IL-1α, IL-1β, IL-6, IL-12, granulocyte colony-stimulating factor (G-SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and TNF-α (tumor necrosis factor alpha). It plays an important role in adaptive immunity.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodim azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500952.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Interleukin-1 as a Key Factor in the Development of Inflammatory Diseases.
Farivar S, et al.
Archives of Pediatric Infectious Diseases, 2(4), e18177-e18177 (2014)
Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis.
Lin XY, et al.
Medicine, 97(15), e0386-e0386 (2018)
The interleukin-1 family: back to the future.
Garlanda C, et al.
Immunity, 39(6), 1003-1018 (2013)
Polymorphism of IL37 gene as a protective factor for autoimmune thyroid disease.
Yan N, et al.
Journal of Molecular Endocrinology, 55(3), 209-218 (2015)
Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.
McCurdy S, et al.
Journal of Immunology, 199(10), 3604-3613 (2017)
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