SAB3500991
Anti-CIITA antibody produced in rabbit
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunoblotting
immunofluorescence
immunohistochemistry
immunoblotting
immunofluorescence
immunohistochemistry
Species reactivity:
rat, mouse, human
Citations:
5
Technique(s):
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
Uniprot accession no.:
产品名称
Anti-CIITA antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 124 kDa
species reactivity
rat, mouse, human
concentration
1 mg/mL
technique(s)
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CIITA(4261)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Immunogen
Antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CIITA.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500991.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodim azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A Raval et al.
Molecular cell, 7(1), 105-115 (2001-02-15)
The CIITA coactivator is essential for transcriptional activation of MHC class II genes and mediates enhanced MHC class I transcription. We now report that CIITA contains an intrinsic acetyltransferase (AT) activity that maps to a region within the N-terminal segment
Inohara et al.
Annual review of biochemistry, 74, 355-383 (2005-06-15)
Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators of apoptosis and pathogen resistance in mammals and plants. A large number of Nods contain leucine-rich repeats (LRRs), hence referred to as NOD-LRR proteins.
Salomé LeibundGut-Landmann et al.
European journal of immunology, 34(6), 1513-1525 (2004-05-27)
The class II transactivator (CIITA) has been referred to as the "master control factor" for the expression of MHC class II (MHCII) genes. As our knowledge on the specificity and function of CIITA grows, it is becoming increasingly evident that
J A Harton et al.
Science (New York, N.Y.), 285(5432), 1402-1405 (1999-08-28)
Class II transactivator (CIITA) is a global transcriptional coactivator of human leukocyte antigen-D (HLA-D) genes. CIITA contains motifs similar to guanosine triphosphate (GTP)-binding proteins. This report shows that CIITA binds GTP, and mutations in these motifs decrease its GTP-binding and
Andreas Neerincx et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 3090-3100 (2014-08-17)
Ag presentation to CD4(+) and CD8(+) T cells depends on MHC class II and MHC class I molecules, respectively. One important regulatory factor of this process is the transcriptional regulation of MHC gene expression. It is well established that MHC
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