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安全信息

SML1984

Sigma-Aldrich

GSK9311

≥98% (HPLC)

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别名:
(R)-N-(1,3-Dimethyl-6-(2-methylpiperazin-1-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-N-ethyl-2-methoxybenzamide, N-[2,3-Dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxybenzamide
经验公式（希尔记法）:
C24H31N5O3
CAS号:
1923851-49-3
分子量:
437.53
MDL编号:
MFCD31382186
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D 90 to 100°, c = 0.3 in methanol

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear (warmed)

储存温度

−20°C

SMILES string

O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(N(CC)C(C4=C(OC)C=CC=C4)=O)C=C2N1C

相关类别

生化/生理作用

GSK9311 is a negative control for the SGC epigenetic probe GSK6853. GSK9311 exhibits 125- and 185-fold reduced potency than its structural analog GSK6853 toward BRPF1 in cell-free and cell-based assays (pIC50 = 6.0/GSK9311 vs. 8.1/GSK6853 in ligand competition binding assay by TR-FRET; IC50 = 3.7 μM/GSK9311 vs. 20 nM/GSK6853 against NanoLuc-BRPF1 bromodomain interaction with Histone H3.3-HaloTag in HEK293 cells), and therefore serves as a good inactive control compound in BRPF1 inhibition studies employing GSK6853. For characterization details of the active probe, GSK6853, please visit the GSK6853 probe summary on the Structural Genomics Consortium (SGC) website.

GSK6853, the active probe, is available from Sigma. To learn more about and purchase GSK6853, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

特点和优势

GSK9311 is the negative control for GSK6853, an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Paul Bamborough et al.
ACS medicinal chemistry letters, 7(6), 552-557 (2016-06-22)
The BRPF (Bromodomain and PHD Finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. A selective benzimidazolone BRPF1 inhibitor showing micromolar activity in a cellular target engagement assay was recently described. Herein, we report the

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