Merck
CN

SML2203

Sigma-Aldrich

SGC-GAK-1N

≥98% (HPLC)

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别名:
CA71, CA93 Negative Control, N-Methyl-6-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine, SGC-GAK-1 Negative Control
Empirical Formula (Hill Notation):
C20H19F3N2O3
分子量:
392.37
NACRES:
NA.77

检测方案

≥98% (HPLC)

形式

powder

颜色

dark green to black

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES string

CN(C1=CC(OC)=C(OC)C(OC)=C1)C2=C3C(C=CC(C(F)(F)F)=C3)=NC=C2

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此商品
SML2220SML2202SML2835
SGC-GAK-1N ≥98% (HPLC)

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SML2203

SGC-GAK-1N

SGC-AAK1-1N ≥98% (HPLC)

Sigma-Aldrich

SML2220

SGC-AAK1-1N

SGC-GAK-1 ≥98% (HPLC)

Sigma-Aldrich

SML2202

SGC-GAK-1

SGC-CAMKK2-1N ≥98% (HPLC)

Sigma-Aldrich

SML2835

SGC-CAMKK2-1N

form

powder

form

powder

form

powder

form

powder

color

dark green to black

color

white to beige

color

white to beige

color

white to beige

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

生化/生理作用

SGC-GAK-1N (CA71) is a structure analog of and the recommended negative control for the ATP-competitive cyclin G-associated kinase (GAK) inhibitor SGC-GAK-1 (CA93) (GAK KD = 1.9 nM/SGC-GAK-1 vs. 7.1 μM/SGC-GAK-1N by ligand competitive binding assay; GAK IC50 = 110 nM/SGC-GAK-1 vs. >50 μM/SGC-GAK-1N by cellular target engagement assay; Dengue viral entry and packaging IC50 = 920 nM/SGC-GAK-1 vs. >10 μM/SGC-GAK-1N). For characterization details of the active probe, SGC-GAK-1, please visit the SGC-GAK-1 probe summary on the Structural Genomics Consortium (SGC) website.

SGC-GAK-1, the active probe, is available from Sigma. To learn more about and purchase SGC-GAK-1, click here.

To learn about other SGC chemical probes, visit sigma.com/sgc

特点和优势

SGC-GAK-1N is a negative control for SGC-GAK-1, a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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