NanoFabTx^™ PLA-nano

The NanoFabTx^™ Polymer drug formulation kit, PLA, for synthesis of 100 and 200 nm particles is a ready-to-use nanoformulation kit for the synthesis of drug-encapsulating PLA-based nanoparticles. This kit provides properly selected PLA based polymers, stabilizer, and protocols for fabrication of PLA nanoparticles by both nanoprecipitation and microfluidic-based synthesis. The microfluidics protocol uses a NanoFabTx^™ device kits (911593, sold separately), which provide all the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).Comprehensive protocols for two different particle synthesis methods are included:

• A nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
• A microfluidics protocol using commercial platforms or syringe pumps.

The NanoFabTx^™ Polymer drug formulation kit, PLA, for synthesis of 100 and 200 nm particles enables users to encapsulate a wide variety of therapeutic drug molecules in PLA-based nanoparticles. Drug encapsulated nanoparticles synthesized with the NanoFabTx^™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, antigen delivery, and vaccine delivery. Poly(D,L-lactic acid) (PLA) is a biocompatible and biodegradable polymer that has been approved by the FDA for biomedical and pharmaceutical applications. Because of their robust mechanical properties and slow degradation, PLA based nanoparticles have been widely used as drug delivery systems to achieve controlled drug release for different types of therapeutic molecules. This kit minimizes laboratory setup with optimized protocols and step-by-step instruction for synthesizing drug-encapsulated nanoparticle-based formulations. It is designed to help pharmaceutical researches achieve reproducible synthesis with high loading efficiencies without the need for lengthy trial-and-error optimization.

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC