Merck
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Success in Perfusion Starts in Process Development

The Smallest, Automated, High-Throughput Bioreactor Yet

The pressure to reduce manufacturing costs is driving the need to improve process efficiency and flexibility, sparking further interest in perfusion technology. As with most processes, success is determined at the process development stage.

The Mobius® Breez Microbioreactor is a 2 mL automated, single-use, perfusion cell culture platform designed to support gentle, adaptable, and reproducible cell culture processes. The system is capable of accelerating a range of applications such as cell line development, media screening and optimization, and early process development.

We invite you to see the Mobius® Breez Microbioreactor in action. Your perfusion journey starts with a Demo! 

Request a Demo
The 2 mL microbioreactor cassette integrates automated pumps, valves, optical sensors, and a cell retention filter.

The 2 mL microbioreactor cassette integrates automated pumps, valves, optical sensors, and a cell retention filter.

A 2 mL Automated Perfusion Cell Culture Platform

  • Achieve high cell densities in a 2 mL perfusion process
  • Run more experiments in parallel for higher efficiency
  • Obtain high-quality perfusate on demand with reliable run-to-run performance
  • Reduce hands-on work with automated control and monitoring
  • Save on development time and costs through operational flexibility 
  • Focus on your goals with easy setup and installation
Mobius® Breez Microbioreactor equipped with 4 pneumatic optical digital (POD) controllers.

Mobius® Breez Microbioreactor

A Complete Platform for Perfusion

Perfusion is becoming a typical approach to achieving upstream process intensification. The ability to scale down these processes, however, has been limited due to a lack of appropriate technologies. The Mobius® Breez Microbioreactor is designed to meet the needs of full control at a small working volume with high-throughput capabilities. The system is comprised of a single-use, 2 mL microbioreactor consumable, four microbioreactor controllers, utility and communication hardware, and a laptop embedded with control software.

Predict Perfusion Performance at Smaller Scales

The Mobius® Breez Microbioreactor allows you to increase efficiency and reduce development timelines and costs over traditional technologies that require more material consumption. You can now achieve high cell densities with integrated pH, DO, temperature and cell density control via OD, and predict the performance of traditional stirred tank reactors at a much smaller volume scale, saving you media and associated costs.

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Related Resources

  • Data Sheet: Mobius® Breez Microbioreactor

    The Mobius® Breez Microbioreactor is a 2 mL automated single-use perfusion cell culture platform designed to support gentle, adaptable, and reproducible cell processes. It allows you to increase efficiency and reduce development timelines and costs over traditional technologies.

  • Spare Parts List: Mobius® Breez Microbioreactor

    This document will help you select and manage the spare parts required for your system.

Webinars

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Scientist at a lab table

A Single-use, Scale down, Predictive Solution for Intensified Perfusion Development

The ability to scale down upstream intensified processes has been limited due to lack of appropriate technologies. This webinar describes a new 2mL single-use perfusion microbioreactor system that fulfills this throughput-performance gap.

Scientist at a lab table

Unleashing the Power of Perfusion: CHOZN® GS-/- Cell Line Development for Intensified Processes

Learn about the advantage of adopting a perfusion-specific CLD process to create more productive clones and find solutions for intensified processing using CHOZN® GS-/- cell line, a suite of best-in-class media, and Mobius® Breez Microbioreactor.

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