Merck
CN

CACNA1D

calcium channel, voltage-dependent, L type, alpha 1D subunit

Synonyms:
CACH3, CACN4, CACNL1A2, CCHL1A2, Cav1.3, SANDD
Species:
Human CACNA1D (776), Mouse Cacna1d (12289), Rat Cacna1d (29716), sheep CACNA1D (101106371), domestic cat CACNA1D (101088394), Domestic Rabbit CACNA1D (100327259), chicken CACNA1D (395895), Horse CACNA1D (100051186), dog CACNA1D (484724), domestic guinea pig Cacna1d (100726255) ...More
UniProtKB ID:
Q01668, B0FYA3, Q13916, Q13931, Q9UDC3
Gene ID:
  • Human(776) Summary: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
  • Mouse(12289) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Rat(29716) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • sheep(101106371) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic cat(101088394) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Domestic Rabbit(100327259) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • chicken(395895) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • Horse(100051186) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • dog(484724) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • domestic guinea pig(100726255) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • cow(408013) calcium channel, voltage-dependent, L type, alpha 1D subunit
  • naked mole-rat(101714832) calcium channel, voltage-dependent, L type, alpha 1D subunit

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
1287303
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Species
human
G-007
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Y0001280
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
G-021
Gabapentin solution, 10 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Y0001805
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
F0030000
Felodipine, European Pharmacopoeia (EP) Reference Standard,
Species
human
1269389
Felodipine, United States Pharmacopeia (USP) Reference Standard,
Species
human
BP777
Felodipine, British Pharmacopoeia (BP) Reference Standard,
Species
human
C2180000
Cinnarizine, European Pharmacopoeia (EP) Reference Standard,
Species
human
PHR1293
Nimodipine, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
AB5158
Anti-Calcium Channel Antibody, Voltage Gated α 1D, Chemicon®, from rabbit,
Species Reactivity
mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
HPA020215
Anti-CACNA1D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
SAB5200022
Monoclonal Anti-CACNA1D antibody produced in mouse, clone S48A-9, 1 mg/mL, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
C1728
Anti-Calcium Channel (α1D Subunit) (L-type of Voltage-gated Ca2+ Channel) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Blocker

Product Number
Description
Species
M8278
Margatoxin, ,
Species
mouse, rat, human
PHR1131
(±)-Verapamil hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
PHR1290
Nifedipine, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
PHR1185
Amlodipine besylate, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
D-035
Diltiazem hydrochloride solution, 1.0 mg/mL in acetonitrile (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Species
human

esiRNA

Product Number
Description
Species
EHU123041
MISSION® esiRNA, targeting human CACNA1D,
Species
human