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Merck
CN

D-035

Diltiazem hydrochloride solution

1.0 mg/mL in acetonitrile (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C22H27ClN2O4S
CAS Number:
33286-22-5
Molecular Weight:
450.98
NACRES:
NA.24
PubChem Substance ID:
329798601
UNSPSC Code:
41116107
EC Number:
200-835-2
MDL number:
MFCD00069252

Key Documents

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InChI key

HDRXZJPWHTXQRI-BHDTVMLSSA-N

InChI

1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

SMILES string

Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile (as free base)

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

Quality Level

300

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

Related Categories

General description

A Certified Spiking Solution® produced for use in clinical toxicology, forensic analysis, or pharmaceutical research applications by GC/Ms or LC/MS. Diltiazem is a pharmaceutical drug in the calcium channel blocker class. Diltiazem is prescribed for the treatment of hypertension and heart conditions such as angina pectoris and some types of arrhythmia.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Regulatory Information

危险化学品
This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Toshio Obata et al.
Clinical biochemistry, 46(1-2), 164-166 (2012-09-25)
The interaction between the PKC and oxygen free radicals. The present study examined the effects of lysophosphatidylcholine (LPC), an endogenous amphophilic lipid metabolite, on 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical (()OH) generation in rat striatum. LPC (50 μM) increased ()OH formation
Ronald W Day
Congenital heart disease, 8(1), 71-77 (2012-08-16)
Right heart catheterization is performed in patients with pulmonary arterial hypertension to determine the severity of disease and their pulmonary vascular reactivity. This study sought to determine whether the acute pulmonary vasodilatory effects of diltiazem and oxygen with nitric oxide
Cardiotoxicity with 5-fluorouracil based agents: rechallenge cannot currently be safely advised.
Jonathan R Dalzell et al.
The American journal of cardiology, 111(3), 454-454 (2013-01-16)
[Optimum heart rate - the current goal of cardiovascular therapy. Position statement of the Polish Cardiac Society Working Group on Cardiovascular Drug Therapy].
Jarosław D Kasprzak et al.
Kardiologia polska, 70(10), 1081-1094 (2012-10-20)
Mustafa Kayan et al.
The Journal of membrane biology, 245(12), 833-840 (2012-08-21)
Non-ionic contrast media (CM) can induce tissue kidney injury via activation of phagocytosis and oxidative stress, although the mechanisms of injury via neutrophils are not clear. We investigated the effects of CM on oxidative stress and Ca²⁺ concentrations in serum
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