Merck
CN

MMP1

matrix metallopeptidase 1 (interstitial collagenase)

Synonyms:
CLG, CLGN
Species:
UniProtKB ID:
Gene ID:
  • Human(4312) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
  • Rat(432357) matrix metalloproteinase 1
  • Rat(300339) matrix metallopeptidase 1 (interstitial collagenase)
  • domestic guinea pig(100727966) matrix metallopeptidase 1 (interstitial collagenase)
  • naked mole-rat(101697620) matrix metallopeptidase 1 (interstitial collagenase)
  • dog(489428) matrix metallopeptidase 1 (interstitial collagenase)
  • chicken(418982) matrix metallopeptidase 1 (interstitial collagenase)
  • sheep(101120355) matrix metallopeptidase 1 (interstitial collagenase)
  • fruit fly(37949) Matrix metalloproteinase 1
  • cow(281308) matrix metallopeptidase 1 (interstitial collagenase)
  • Horse(100033896) matrix metallopeptidase 1 (interstitial collagenase)
  • Domestic Rabbit(100009110) matrix metallopeptidase 1 (interstitial collagenase)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Product Number
Description
Species
Human MMP-1 ELISA Kit, for serum, plasma, cell culture supernatant and urine,
Species
human
Human MMP-1 ELISA Kit, for cell and tissue lysates,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Matrix Metalloproteinase-1 antibody produced in goat, affinity isolated antibody, lyophilized powder,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-MMP-1 (Ab-1) Mouse mAb (41-1E5), liquid, clone 41-1E5, Calbiochem®,
Species Reactivity
human
Application
Anti-MMP-1 Antibody, a.a. 332-350 hMMP1, clone 41-1E5, clone 41-1E5, Chemicon®, from mouse,
Species Reactivity
human, rabbit
Application
ELISA
immunohistochemistry

western blot
Anti-MMP-1 Antibody, hinge region, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
western blot
Anti-MMP-1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
2,2′:5′,2′′:5′′,2′′′-Quaterthiophene, 96%,
Species
human, rat, mouse
CP-471474, ≥98% (HPLC),
Species
human, rat, mouse
CP-101537, ≥98% (HPLC),
Species
human, rat, mouse
Marimastat, ≥98% (HPLC),
Species
human, rat, mouse
PD166793 hydrate, ≥98% (HPLC),
Species
human, rat, mouse

Proteins

Product Number
Description
Species
MMP-1 human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Species
human
Matrix Metalloproteinase-1 human, recombinant, expressed in NSO cells, >95% (SDS-PAGE), buffered aqueous solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human MMP1,
Species
human