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RAB0361

Human MMP-1 ELISA Kit

Name: Human MMP-1 ELISA Kit
Brand: SIGMA

for serum, plasma, cell culture supernatant and urine

Synonym(s):

MMP-1, Matrix metalloproteinase-1

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About This Item

NACRES:

NA.32

UNSPSC Code:

41116158

Gene information:

human ... MMP1(4312)

Input:

sample type plasma
sample type cell culture supernatant(s)
sample type serum
sample type urine

Species reactivity:

human

Storage temp.:

−20°C

Shipped in:

wet ice

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species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable, capture ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum
sample type urine

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/mL
standard curve range: 24.69-18000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MMP1(4312)

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Related Categories

Enzyme-Linked Immunosorbent Assay (ELISA) Kits

Immunoassay Platform Solutions

General description

The Human MMP-1 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human MMP-1 pro and active forms in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human MMP1

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human MMP-1 ELISA Kit has been used in ELISA assays.

Biochem/physiol Actions

Matrix metalloproteinases (MMPs) enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens, aggrecan, serpins, and α2-macroglobulin. It is overexpressed in lumbar intervertebral disc degeneration (IDD). It might also be associated with osteoarthritis. MMP-1 is linked with juvenile idiopathic arthritis. Genetic variations in MMP-1 can affect the susceptibility and severity of this disease.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.

Description

SDS

RABELADEELISA 5X Assay/Sample Diluent Buffer E (Item E2)SDS

RABSTOP3ELISA Stop Solution (Item I)SDS

RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS

RABWASH420X Wash Buffer (Item B)SDS

pictograms

GHS05

signalword

Warning

hcodes

H290

pcodes

P234 - P390

Hazard Classifications

Met. Corr. 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

12 - Non Combustible Liquids

Regulatory Information

低风险生物材料

常规特殊物品

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Certificates of Analysis (COA)

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The development of a matrix metalloproteinase-1 biosensor based on the surface plasmon resonance imaging technique

Tokarzewicz A, et al.

Analytical Methods : Advancing Methods and Applications, 8(34), 428-6435 (2016)

Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.

Abd-Allah SH, et. al.

IUBMB Life, 67, 934-942 (2015)

Expression profiles of MMP-1 and TIMP-1 in lumbar intervertebral disc degeneration.

Deng B, et. al.

Genetics and molecular research : GMR, 14, 19080-19086 (2015)

MMP-2 functions as an early response protein in ovarian cancer metastasis.

Kenny HA, et. al.

Cell Cycle, 8, 683-688 (2009)

Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.

Vincenti MP and Brinckerhoff CE

Arthritis Research, 4, 157-164 (2002)

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Global Trade Item Number

SKU	GTIN
RAB0361-1KT	04061834961925

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