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RAB0361

Human MMP-1 ELISA Kit

for serum, plasma, cell culture supernatant and urine

Synonym(s):

MMP-1, Matrix metalloproteinase-1

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About This Item

NACRES:
NA.32
UNSPSC Code:
41116158

Key Documents

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Product Name

Human MMP-1 ELISA Kit, for serum, plasma, cell culture supernatant and urine

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable
capture ELISA: suitable

input

sample type plasma
sample type cell culture supernatant(s)
sample type serum
sample type urine

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 8 pg/mL
standard curve range: 24.69-18000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MMP1(4312)

Related Categories

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Human MMP-1 ELISA Kit has been used in ELISA assays.

Biochem/physiol Actions

Matrix metalloproteinases (MMPs) enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens, aggrecan, serpins, and α2-macroglobulin. It is overexpressed in lumbar intervertebral disc degeneration (IDD). It might also be associated with osteoarthritis. MMP-1 is linked with juvenile idiopathic arthritis. Genetic variations in MMP-1 can affect the susceptibility and severity of this disease.

General description

The Human MMP-1 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human MMP-1 pro and active forms in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human MMP1

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

pictograms

Corrosion
GHS05

signalword

Warning

hcodes

H290

Hazard Classifications

Met. Corr. 1

Storage Class

8B - Non-combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
0417M0169
0216K0169
0213K0169
1219J0169
1103J0169

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Influence of Matrix metalloproteinase 1 and 3 genetic variations on susceptibility and severity of juvenile idiopathic arthritis.
Abd-Allah SH, et. al.
IUBMB Life, 67, 934-942 (2015)
The development of a matrix metalloproteinase-1 biosensor based on the surface plasmon resonance imaging technique
Tokarzewicz A, et al.
Analytical Methods : Advancing Methods and Applications, 8(34), 428-6435 (2016)
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
Vincenti MP and Brinckerhoff CE
Arthritis Research, 4, 157-164 (2002)
Matrix metalloproteinases: role in skeletal development and growth plate disorders.
Malemud CJ
Frontiers in Bioscience, 11, 1702-1715 (2006)
Regulation of matrix metalloproteinase expression in tumor invasion.
Westermarck J and Kahari VM
FEBS Journal, 13, 781-792 (1999)
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