Merck
CN

TTR

transthyretin

Synonyms:
CTS, CTS1, HsT2651, PALB, TBPA
Species:
UniProtKB ID:
Gene ID:
  • Human(7276) Summary: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]
  • Mouse(22139) transthyretin
  • Rat(24856) transthyretin
  • fruit fly(246932) tetrapter
  • chicken(396277) transthyretin
  • Zebrafish(449556) transthyretin (prealbumin, amyloidosis type I)
  • domestic cat(101085927) transthyretin
  • dog(480167) transthyretin
  • cow(280948) transthyretin
  • sheep(443389) transthyretin
  • domestic guinea pig(100735950) transthyretin
  • naked mole-rat(101726783) transthyretin

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Small Molecule - Antagonist

Product Number
Description
Species
Diphenyl ether, ReagentPlus®, ≥99%,
Species
human
Diphenyl ether, ReagentPlus®, 99%,
Species
human
Diphenyl ether, ≥99%, FG,
Species
human
N-Phenylanthranilic acid, 98%,
Species
human
Nitrendipine, >95%, powder,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-TTR antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0290, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Transthyretin Antibody, clone 7G8-E11-E7, clone 7G8-E11-E7, from mouse,
Species Reactivity
human
Application
ELISA
western blot
Anti-TTR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

western blot
Anti-Transthyretin antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-TTR antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human, mouse, rat
Application
ELISA
immunohistochemistry

Proteins

Product Number
Description
Species
Prealbumin from human plasma, lyophilized powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Ttr,
Species
mouse
MISSION® esiRNA, targeting human TTR,
Species
human