P1742
Prealbumin from human plasma
lyophilized powder
Synonym(s):
Thyroxine binding prealbumin, Transthyretin
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About This Item
Biological source:
human plasma
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Technique(s):
immunoelectrophoresis: suitable, immunoprecipitation (IP): suitable
Impurities:
Infectious agents, tested
biological source
human plasma
Quality Level
assay
≥95% (SDS-PAGE)
form
lyophilized powder
technique(s)
immunoelectrophoresis: suitable, immunoprecipitation (IP): suitable
impurities
Infectious agents, tested
solubility
H2O: soluble 1 mg/mL
ε (extinction coefficient)
13.5 at 280 nm at 1%
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TTR(7276)
General description
Human prealbumin is a product of chromosome 18. It is a serum protein, synthesized primarily in the liver. It is a tetrameric protein with a molecular weight of 55 kDa. Human prealbumin is composed of four identical non-covalently bound monomers of 127 amino acid residues arranged with tetrahedral symmetry.
Application
Prealbumin from human plasma has been used as a positive control in immunoprecipitation as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.
Human prealbumin was used to study reduced transthyretin expression in sera of lung cancer.
Biochem/physiol Actions
Prealbumin levels are indictors of malnutrition and may be modulated during inflammation. It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis. Low levels of prealbumin poses high risk to heart failure (HF).
Human prealbumin has been observed in carcinoid tumors.
Packaging
Package size based on protein content
Physical form
Lyophilized powder containing sodium phosphate and NaCl
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
高风险级别生物产品--人源产品
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K Nelson et al.
International journal of cancer, 15(5), 806-814 (1975-05-15)
Spleen cells from BALB/c mice which either bore syngeneic sarcomas or were normal controls were cultured in vitro. The culture supernatants of spleen cells from tumor-bearing mice inhibited (blocked) specific cell-mediated cytotoxicity to the tumor borne by the spleen donor.
Haruki Koike et al.
Journal of neurology, 255(10), 1526-1533 (2008-09-30)
Through the development of gene diagnostic techniques, late-onset transthyretin Met30-associated familial amyloid polyneuropathy (FAP TTR Met30) has been shown to be more prevalent than is generally believed. To examine the electrophysiological features of late-onset FAP TTR Met30 unrelated to endemic
Prealbumin is as important as albumin in the nutritional assessment of hemodialysis patients
Chertow GM, et al.
Kidney International, 58(6), 2512-2517 (2000)
Takashi Ito et al.
Internal medicine (Tokyo, Japan), 45(20), 1173-1175 (2006-11-16)
Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a
Minori Kodaira et al.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 18(1), 10-18 (2011-01-26)
The process of deterioration of peripheral nerve function in familial amyloid polyneuropathy (FAP) with amyloidogenic transthyretin (ATTR) Val30Met has not been systematically evaluated hitherto. We performed nerve conduction studies in 69 patients with FAP with ATTR Val30Met from one of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P1742-1MG | 04061826739686 |
| P1742-.5MG | 04061833421383 |
| P1742-5MG | 04061834356240 |
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