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P1742

Prealbumin from human plasma

lyophilized powder

Synonym(s):

Thyroxine binding prealbumin, Transthyretin

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About This Item

CAS Number:
87090-18-4
UNSPSC Code:
12352202
NACRES:
NA.25
MDL number:
MFCD00132069
Biological source:
human plasma
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Technique(s):
immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable
Impurities:
Infectious agents, tested

Key Documents

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Product Name

Prealbumin from human plasma, lyophilized powder

biological source

human plasma

assay

≥95% (SDS-PAGE)

form

lyophilized powder

technique(s)

immunoelectrophoresis: suitable
immunoprecipitation (IP): suitable

impurities

Infectious agents, tested

solubility

H2O: soluble 1 mg/mL

ε (extinction coefficient)

13.5 at 280 nm at 1%

UniProt accession no.

P02766

storage temp.

−20°C

Quality Level

200

Gene Information

human ... TTR(7276)

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Application

Human prealbumin was used to study reduced transthyretin expression in sera of lung cancer.
Prealbumin from human plasma has been used as a positive control in immunoprecipitation as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.

Biochem/physiol Actions

Human prealbumin has been observed in carcinoid tumors.
Prealbumin levels are indictors of malnutrition and may be modulated during inflammation. It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis. Low levels of prealbumin poses high risk to heart failure (HF).

General description

Human prealbumin is a product of chromosome 18. It is a serum protein, synthesized primarily in the liver. It is a tetrameric protein with a molecular weight of 55 kDa. Human prealbumin is composed of four identical non-covalently bound monomers of 127 amino acid residues arranged with tetrahedral symmetry.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing sodium phosphate and NaCl

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000507926
0000507926
0000496720
0000496720
0000497072

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the molecular weight of Product P1742, Prealbumin from human plasma?

    The molecular weight has been reported to be 54,980 Daltons. Referece: The Plasma Proteins, 2nd edition (1975) p. 60.

  6. What is the volume from which Product P1742, Prealbumin from human plasma, is lyophilized from?

    The starting volume is lot specific. Please contact Technical Service to obtain the exact volume of your lot of interest.

  7. What is the solubility of Product P1742, Prealbumin from human plasma?

    This product is soluble in water at 1mg/mL.

  8. What is the purity of Product P1742, Prealbumin from human plasma?

    Information about purity can be found on the lot specific certificate of analysis.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Serum albumin and prealbumin in calorically restricted, nondiseased individuals: a systematic review
Lee JL, et al
The American Journal of Medicine, 128(9), 1023-e1-1023-e1 (2015)
K Tashima et al.
Journal of the neurological sciences, 171(1), 19-23 (1999-11-24)
Since 1990, liver transplantation for familial amyloidotic polyneuropathy (FAP) has been carried out world-wide, and the outcome of the procedure seems to be promising. FAP is inherited systemic disease caused by mutated transthyretin. The most common cause is the valine
Gen Sobue
Rinsho shinkeigaku = Clinical neurology, 43(11), 769-774 (2004-05-22)
A nationwide study of CMT and FAP has been performed. In FAP TTR Met30 families with late onset, neuropathy showed male preponderance, low penetrance, little relationship to endemic foci, sensorimotor symptoms beginning distally in the lower extremities with disturbance of
David Adams et al.
Presse medicale (Paris, France : 1983), 41(9 Pt 1), 793-806 (2012-02-22)
The treatment of familial amyloid polyneuropathies (FAP) is complex and requires a neurological and cardiological multidisciplinary coverage. It includes specific treatments to control the progression of the systemic amyloidogenesis, the symptomatic treatment of the peripheral and autonomic neuropathy (digestive, urinary
J P Hegmann
Behavior genetics, 9(3), 165-175 (1979-05-01)
Behavioral and physiological scores from 697 mice sampled from lines at various times during their response to bidirectional selection for divergent caudal nerve conduction velocity suggest broad-reaching behavioral effects of the gene differences among lines. Sciatic nerve conduction velocity differences
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