103276
哈尔满碱
98%
别名:
1-甲基-9H-吡啶并[3,4-b]吲哚, 2-甲基-β-咔啉, 阿锐碱
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关于此项目
经验公式（希尔记法）:
C12H10N2
化学文摘社编号:
分子量:
182.22
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-642-2
Beilstein/REAXYS Number:
143898
MDL number:
Assay:
98%
Quality Segment
assay
98%
drug control
stupéfiant (France)
mp
235-238 °C (lit.)
solubility
methanol: soluble 50mg/ml
SMILES string
Cc1nccc2c3ccccc3[nH]c12
InChI
1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
InChI key
PSFDQSOCUJVVGF-UHFFFAOYSA-N
Gene Information
human ... CYP2D6(1565)
rat ... Gabra2(29706)
General description
- Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
- It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
- Blood harmane concentration is elevated in essential tremor, late-life neurological disease.
Application
- Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
- It was used to study interactions of norharman and harman with DNA.
- It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.
Biochem/physiol Actions
I1 咪唑啉结合位点激动剂。
Preparation Note
Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Irrit. 2
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)