105937
3,4,4′-Trichlorocarbanilide
99%
Synonym(s):
1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl)urea, TCC, Triclocarban
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About This Item
Linear Formula:
Cl2C6H3NHCONHC6H4Cl
CAS Number:
Molecular Weight:
315.58
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Agency
EPA 1694
vapor pressure
<0.1 mmHg ( 25 °C)
Assay
99%
form
solid
mp
254-256 °C (lit.)
solubility
methanol: soluble
application(s)
environmental
functional group
amine
chloro
SMILES string
Clc1ccc(NC(=O)Nc2ccc(Cl)c(Cl)c2)cc1
InChI
1S/C13H9Cl3N2O/c14-8-1-3-9(4-2-8)17-13(19)18-10-5-6-11(15)12(16)7-10/h1-7H,(H2,17,18,19)
InChI key
ICUTUKXCWQYESQ-UHFFFAOYSA-N
Gene Information
human ... EPHX2(2053)
mouse ... Ephx2(13850)
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General description
3,4,4′-Trichlorocarbanilide(TCC) is employed as bacteriostat and antimicrobial agent in bar soaps, cosmetics and other personal care prducts.TCC is a toxic, persistent and potentially bioaccumulative polychlorinated binuclear aromatic urea pesticide.
Application
3,4,4′-Trichlorocarbanilide was used to develop a sensitive analytical method to determine triclocarban and environmental phenols in breast milk using isotope dilution on-line solid-phase extraction coupled with HPLC–tandem mass spectrometry. 3,4,4′-Trichlorocarbanilide was used in quantitative structure-activity relationship (QSAR)analyses conducted to study the co-occurrence of Triclocarban and Triclosan in U.S. Water Resources.
Biochem/physiol Actions
3,4,4′-Trichlorocarbanilide interferes with mammalian reproduction and can cause methemoglobinemia in humans.
Disclaimer
The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
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Biodegradation of 3, 4, 4'-trichlorocarbanilide, TCC?, in sewage and activated sludge.
Gledhill WE.
Water Research, 9(7), 649-654 (1975)
Rolf U Halden et al.
Environmental science & technology, 39(6), 1420-1426 (2005-04-12)
Triclocarban (TCC) and triclosan (TCS) are antimicrobial additives in personal care products. Whereas TCS has been studied extensively, the environmental fate of TCC remains largely unknown. To address this data gap, we performed quantitative structure-activity relationship (QSAR) analyses that suggested
Rong Chu et al.
Oncotarget, 7(48), 78958-78970 (2016-10-16)
Microtubule targeting agents (MTAs) characteristically promote phosphorylation and degradation of Mcl-1, and this represents a critical pro-apoptotic signal in mitotic death. While several phosphorylation sites and kinases have been implicated in mitotic arrest-induced Mcl-1 phosphorylation, a comprehensive biochemical analysis has
Arjun K Venkatesan et al.
Journal of hazardous materials, 229-230, 29-35 (2012-06-30)
The antimicrobial agents triclosan (TCS), triclocarban (TCC) and their associated transformation products are of increasing concern as environmental pollutants due to their potential adverse effects on humans and wildlife, including bioaccumulation and endocrine-disrupting activity. Analysis by tandem mass spectrometry of
Jian-Liang Zhao et al.
Water research, 47(1), 395-405 (2012-11-07)
Triclosan (TCS) and triclocarban (TCC) are two commonly used personal care products. They may enter into aquatic environments after consumption and pose potential risks to aquatic organisms. We investigated the occurrence and fate of TCS and TCC in five large
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