115053
4-Nitrophenethyl bromide
98%
Synonym(s):
1-(2-Bromoethyl)-4-nitrobenzene, 2-(4-Nitrophenyl)ethyl bromide
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About This Item
Linear Formula:
O2NC6H4CH2CH2Br
CAS Number:
Molecular Weight:
230.06
EC Number:
226-271-7
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
1909321
MDL number:
Assay:
98%
Form:
solid
InChI key
NTURQZFFJDCTMZ-UHFFFAOYSA-N
InChI
1S/C8H8BrNO2/c9-6-5-7-1-3-8(4-2-7)10(11)12/h1-4H,5-6H2
SMILES string
[O-][N+](=O)c1ccc(CCBr)cc1
assay
98%
form
solid
functional group
bromo, nitro
General description
4-nitrophenethyl bromide is an electrophile which accepts a lone pair of electrons from one of the nitrogen atoms in the polyazamacrocycle.
Application
4-nitrophenethyl bromide is used a s a GST T1-1 substrate for identifying many kinetic parameters (Km, Kcat) for hGST T1-1 variants.
Biochem/physiol Actions
4-Nitrophenethyl bromide is used as a marker in for the θ-class of glutathione S-transferases (GSTs). It activates the human θ-class glutathione transferase T1-1 enzyme.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Regulatory Information
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M F Lopez et al.
Biochimica et biophysica acta, 1205(1), 29-38 (1994-03-16)
A novel glutathione S-transferase (GST) was purified from broccoli (Brassica oleracea var. italica). Partial amino-acid sequencing indicated that the protein shared significant homology with several different plant GSTs from maize, silene, Dianthus, Nicotiana and Triticum, but little homology to yeast
Abeer Shokeer et al.
The Biochemical journal, 388(Pt 1), 387-392 (2005-02-03)
GST (glutathione transferase) T1-1 plays an important role in the biotransformation of halogenated alkanes, which are used in large quantities as solvents and occur as environmental pollutants. Many reactions that are catalysed by GST T1-1 qualify as detoxification processes, but
Amalia Rodríguez et al.
Journal of colloid and interface science, 248(2), 455-461 (2005-11-18)
The reactions 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane + OH(-) and 2-(p-nitrophenyl)ethyl bromide + OH(-) were studied in tetradecyltrimethylamonium bromide, TTAB, and TTAB-pentanol micellar solutions. The influence of changes in the surfactant concentration as well as changes in the hydroxide ion concentration on the observed
Birute Surinenaite et al.
Biotechnology and applied biochemistry, 36(Pt 1), 47-55 (2002-08-01)
The lipase from Pseudomonas mendocina 3121-1 was found to be homogeneous with a molecular mass of 30 kDa by SDS/PAGE. It is composed of two identical subunits. A molecular mass of 62 kDa was determined by gel chromatography on a
Kerstin Broo et al.
Journal of molecular biology, 318(1), 59-70 (2002-06-11)
The correlation between sequence diversity and enzymatic function was studied in a library of Theta class glutathione transferases (GSTs) obtained by stochastic recombination of fragments of cDNA encoding human GST T1-1 and rat GST T2-2. In all, 94 randomly picked
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