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115169

Tetramethylthiourea

Name: Tetramethylthiourea
Brand: ALDRICH

98%

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About This Item

Linear Formula:

(CH₃)₂NCSN(CH₃)₂

CAS Number:

2782-91-4

Molecular Weight:

132.23

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24847202

EC Number:

220-488-0

Beilstein/REAXYS Number:

1744916

MDL number:

MFCD00008324

Assay:

98%

Form:

solid

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Properties

Quality Level

100

assay

98%

form

solid

bp

245 °C (lit.)

mp

75-77 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C)C(=S)N(C)C

InChI

1S/C5H12N2S/c1-6(2)5(8)7(3)4/h1-4H3

InChI key

MNOILHPDHOHILI-UHFFFAOYSA-N

Description

General description

Tetramethylthiourea molecule shows crystallographic two-fold symmetry with weak hydrogen bond packing, which connects the molecules to form layers.

Application

Tetramethylthiourea forms BF3 adduct with tetramethylselenourea.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Schwann cell proliferation in the sciatic nerve of hypothyroid chick embryos studied by autoradiography and image analysis.

Y Usson et al.

Journal of neurocytology, 17(5), 639-648 (1988-10-01)

The proliferation of Schwann cells in the sciatic nerve of chick was studied from day 11 to day 27 of development in control and thyroid-deficient embryos. Hypothyroidism was induced by tetramethylthiourea injection on days 8 and 19 of incubation. The

Tuning the reactivity of chelated dinuclear Pt(II) complexes through a flexible diamine linker. A detailed kinetic and mechanistic study.

Allen Mambanda et al.

Dalton transactions (Cambridge, England : 2003), 39(15), 3595-3608 (2010-04-01)

The rate of displacement of the aqua ligands by three neutral nucleophiles (Nu) of different steric demands, namely thiourea (tu), N,N'-dimethylthiourea (dmtu) and N,N,N',N'-tetramethylthiourea (tmtu) and an anionic nucleophile (I(-)) in complexes of the form [{Pt(H(2)O)}(2)(N,N,N',N'-tetrakis(2-pyridylmethyl)-N(CH(2))(n)N](CF(3)SO(3))(4), n = 2 (En);

Studies on the goitrogenic mechanism of action of N,N,N',N'-tetramethylthiourea.

Alexius Freyberger et al.

Toxicology, 217(2-3), 169-175 (2005-11-22)

N,N,N',N'-Tetramethylthiourea (TMTU) is a rat goitrogen inducing thyroid hyperplasia, hypertrophy, and tumor formation. Little is known about the exact underlying mechanism of action. As thyroid peroxidase (TPO) and type I iodothyronine deiodinase (ID-I) have been established as targets of goitrogenic

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Global Trade Item Number

SKU	GTIN
115169-25G	04061838703118