115169
Tetramethylthiourea
98%
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About This Item
Linear Formula:
(CH3)2NCSN(CH3)2
CAS Number:
Molecular Weight:
132.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
220-488-0
Beilstein/REAXYS Number:
1744916
MDL number:
Assay:
98%
Form:
solid
InChI key
MNOILHPDHOHILI-UHFFFAOYSA-N
InChI
1S/C5H12N2S/c1-6(2)5(8)7(3)4/h1-4H3
SMILES string
CN(C)C(=S)N(C)C
assay
98%
form
solid
bp
245 °C (lit.)
mp
75-77 °C (lit.)
storage temp.
2-8°C
Quality Level
Related Categories
General description
Tetramethylthiourea molecule shows crystallographic two-fold symmetry with weak hydrogen bond packing, which connects the molecules to form layers.
Application
Tetramethylthiourea forms BF3 adduct with tetramethylselenourea.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Y Usson et al.
Journal of neurocytology, 17(5), 639-648 (1988-10-01)
The proliferation of Schwann cells in the sciatic nerve of chick was studied from day 11 to day 27 of development in control and thyroid-deficient embryos. Hypothyroidism was induced by tetramethylthiourea injection on days 8 and 19 of incubation. The
[Effect of thyroid deficiency on cutaneous nerve development in chickens].
R Saxod et al.
Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 294(1), 19-24 (1982-01-04)
Allen Mambanda et al.
Dalton transactions (Cambridge, England : 2003), 39(15), 3595-3608 (2010-04-01)
The rate of displacement of the aqua ligands by three neutral nucleophiles (Nu) of different steric demands, namely thiourea (tu), N,N'-dimethylthiourea (dmtu) and N,N,N',N'-tetramethylthiourea (tmtu) and an anionic nucleophile (I(-)) in complexes of the form [{Pt(H(2)O)}(2)(N,N,N',N'-tetrakis(2-pyridylmethyl)-N(CH(2))(n)N](CF(3)SO(3))(4), n = 2 (En);
Alexius Freyberger et al.
Toxicology, 217(2-3), 169-175 (2005-11-22)
N,N,N',N'-Tetramethylthiourea (TMTU) is a rat goitrogen inducing thyroid hyperplasia, hypertrophy, and tumor formation. Little is known about the exact underlying mechanism of action. As thyroid peroxidase (TPO) and type I iodothyronine deiodinase (ID-I) have been established as targets of goitrogenic
Jiqin Liu et al.
Molecular immunology, 45(15), 3984-3989 (2008-07-29)
N-Acetylcysteine (NAC) has been widely used as an antioxidant in research, however, it has also been found to reduce the binding of TNF to its receptor independent of its antioxidative role. In this study, we investigated the effect of NAC
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