120847
2-Fluorobenzoyl chloride
99%
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About This Item
Linear Formula:
FC6H4COCl
CAS Number:
Molecular Weight:
158.56
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
206-887-2
Beilstein/REAXYS Number:
636864
MDL number:
Assay:
99%
Quality Level
assay
99%
refractive index
n20/D 1.536 (lit.)
bp
90-92 °C/15 mmHg (lit.)
mp
4 °C (lit.)
density
1.328 g/mL at 25 °C (lit.)
functional group
acyl chloride, fluoro
SMILES string
Fc1ccccc1C(Cl)=O
InChI
1S/C7H4ClFO/c8-7(10)5-3-1-2-4-6(5)9/h1-4H
InChI key
RAAGZOYMEQDCTD-UHFFFAOYSA-N
General description
2-Fluorobenzoyl chloride reacts with ethyl 5-amino-1-methylpyrazole-4-carboxylate to give N-mono-N,N-di-substituted intermediate which on ring closure yields heteroannulated oxazinone.
Application
2-Fluorobenzoyl chloride has been used in the preparation of 3-(N-Hydroxycarbamimidoyl)-benzoic acid methyl ester. It has been used to develop an hollow-fiber liquid phase microextraction with in situ derivatization method coupled with HPLC-UV for the determination of metformin hydrochloride in biological fluids.
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
251.6 °F - closed cup
flash_point_c
122 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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P Jakobsen et al.
Bioorganic & medicinal chemistry, 8(12), 2803-2812 (2000-12-29)
The synthesis of a series of 2-aryl substituted hetero annulated 1,3-oxazin-4-ones and their evaluation as specific inhibitors of the tissue factor (TF)/factor VIIa (FVIIa)-induced pathway of coagulation is reported. Inhibitory activities (IC50 values) in the range 0.64 to > 40
Lulin Zhou et al.
Magnetic resonance in chemistry : MRC, 54(3), 222-226 (2015-11-03)
A new method utilization of NMR spectra was developed for structural and quantitative analysis of enol forms of acetylacetone and ethyl acetoacetate. Acetylacetone and ethyl acetoacetate were determined by (19) F NMR upon derivatisation with р-fluorobenzoyl chloride. The base-catalyzed derivatives
Dima A Sabbah et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 15(4), 417-429 (2018-09-13)
Phosphoinositide 3-kinase α (PI3Kα) has emerged as a promising target for anticancer drug design. Target compounds were designed to investigate the effect of the p-OCH3 motifs on ligand/PI3Kα complex interaction and antiproliferative activity. Synthesis of the proposed compounds, biological examination
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 120847-100G | 04061838345349 |
| 120847-25G | 04061836682057 |