125180
1-(3-Chlorophenyl)piperazine hydrochloride
99%
Synonym(s):
m-CPP
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About This Item
Empirical Formula (Hill Notation):
C10H13ClN2 · xHCl
CAS Number:
Molecular Weight:
196.68 (free base basis)
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
265-718-0
MDL number:
Assay:
99%
Form:
powder
Product Name
1-(3-Chlorophenyl)piperazine hydrochloride, 99%
InChI key
MHXPYWFZULXYHT-UHFFFAOYSA-N
InChI
1S/C10H13ClN2.ClH/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13;/h1-3,8,12H,4-7H2;1H
SMILES string
Cl.Clc1cccc(c1)N2CCNCC2
assay
99%
form
powder
Quality Level
Gene Information
rat ... Htr1a(24473)
drug control
kontrollierte Droge in Deutschland
mp
210-214 °C (dec.) (lit.)
solubility
methanol: soluble
functional group
chloro
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Application
1-(3-Chlorophenyl)piperazine hydrochloride (CPP) has been used in determination of designer piperazines in urine specimens using GC-MS and LC-ESI-MS. CPP has been used to investigate the in vitro efficacy of newly synthesized compounds such as fluoroquinolones (norfloxacine and lomefloxacine) against Philasterides dicentrarchi .
Biochem/physiol Actions
1-(3-Chlorophenyl)piperazine induces hypophagia in food-deprived and freely feeding rats. CPP has affinity for 11 neurotransmitter receptor binding sites in human brain membranes.
5-HT2c serotonin receptor agonist; metabolite of trazodone.
General description
1-(3-Chlorophenyl)piperazine hydrochloride is sold as Ecstasy mimic tablets and is the major metabolite of the antidepressant medications trazodone and nefazodone.
Legal Information
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.
English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Regulatory Information
监管及禁止进口产品
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Horst Schicknick et al.
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1-(m-chlorophenyl)piperazine (mCPP) interactions with neurotransmitter receptors in the human brain.
A Hamik et al.
Biological psychiatry, 25(5), 569-575 (1989-03-01)
The affinity of 1-(m-chlorophenyl)piperazine (mCPP) for 11 neurotransmitter receptor binding sites was determined in human brain membranes. mCPP is essentially equipotent at all 5-hydroxytryptamine (5-HT) receptor subtypes (IC50 values ranging from 360 to 1300 nM). The drug displays similar affinity
G A Kennett et al.
British journal of pharmacology, 103(4), 2016-2020 (1991-08-01)
1. 1-3(Chlorophenyl)piperazine (mCPP) (5 mg kg-1, i.p.) inhibited 2 h food intake in rats previously deprived of food for one day. Ten 5-hydroxytryptamine (5-HT) antagonists given s.c. opposed this hypophagic response. Calculated ID50 values correlated significantly with reported affinities (r
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