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126462

6,7-Dimethyl-2,3-di(2-pyridyl)quinoxaline

Name: 6,7-Dimethyl-2,3-di(2-pyridyl)quinoxaline
Brand: ALDRICH

98%

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₆N₄

CAS Number:

6627-38-9

Molecular Weight:

312.37

NACRES:

NA.22

PubChem Substance ID:

24847727

UNSPSC Code:

12352100

EC Number:

229-592-0

MDL number:

MFCD00006730

Assay:

98%

Form:

powder

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Properties

Quality Level

100

assay

98%

form

powder

mp

191-193 °C (lit.)

SMILES string

Cc1cc2nc(-c3ccccn3)c(nc2cc1C)-c4ccccn4

InChI

1S/C20H16N4/c1-13-11-17-18(12-14(13)2)24-20(16-8-4-6-10-22-16)19(23-17)15-7-3-5-9-21-15/h3-12H,1-2H3

InChI key

NACXMBPTPBZQHY-UHFFFAOYSA-N

Description

Application

6,7-Dimethyl-2,3-di-(2-pyridyl)quinoxaline has been used as an internal standard to investigate the clinical pharmacokinetics of nelfinavir mesylate, a potent inhibitor of HIV-1 protease.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Determination of rifampicin in human plasma by high-performance liquid chromatography coupled with ultraviolet detection after automatized solid-liquid extraction.

B Louveau et al.

Biomedical chromatography : BMC, 30(12), 2009-2015 (2016-06-10)

A precise and accurate high-performance liquid chromatography (HPLC) quantification method of rifampicin in human plasma was developed and validated using ultraviolet detection after an automatized solid-phase extraction. The method was validated with respect to selectivity, extraction recovery, linearity, intra- and

Vancomycin Population Pharmacokinetics in Critically Ill Adults During Sustained Low-Efficiency Dialysis.

Salmaan Kanji et al.

Clinical pharmacokinetics, 59(3), 327-334 (2019-09-01)

Sustained low-efficiency dialysis (SLED) is a hybrid form of dialysis that is increasingly used in critically ill patients with kidney injury and hemodynamic instability. Antimicrobial dosing for patients receiving SLED is informed by pharmacokinetic studies that describe the drug clearance.

High-performance liquid chromatographic method for the determination of nelfinavir, a novel HIV-1 protease inhibitor, in human plasma.

E Y Wu et al.

Journal of chromatography. B, Biomedical sciences and applications, 695(2), 373-380 (1997-08-01)

Nelfinavir mesylate, a potent and orally bioavailable inhibitor of HIV-1 protease (Ki=2 nM), has undergone Phase III clinical evaluation in a large population of HIV-positive patients. A high-performance liquid chromatography analytical method was developed to determine the pharmacokinetic parameters of

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Global Trade Item Number

SKU	GTIN
126462-5G	04061833320150