127221
Di(2-pyridyl) ketone
99%
Synonym(s):
2,2′-Carbonyldipyridine, 2,2′-Dipyridyl ketone
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About This Item
Empirical Formula (Hill Notation):
C11H8N2O
CAS Number:
Molecular Weight:
184.19
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
243-067-3
Beilstein/REAXYS Number:
126598
MDL number:
Assay:
99%
Form:
solid
InChI key
QPOWUYJWCJRLEE-UHFFFAOYSA-N
InChI
1S/C11H8N2O/c14-11(9-5-1-3-7-12-9)10-6-2-4-8-13-10/h1-8H
SMILES string
O=C(c1ccccn1)c2ccccn2
assay
99%
form
solid
Quality Level
Gene Information
human ... EPHX2(2053)
mouse ... Ephx2(13850)
functional group
ketone
Related Categories
Application
di-2-Pyridyl ketone has been used in the preparation of unusual {Ni(II)(3)Ln(III)(μ-OR)(6)}(3+) complexes with a "star" topology. Its monoanionic form has been used in the synthesis of triangular Ni(2)M (M = lanthanide, Y) complexes.
Biochem/physiol Actions
The Schiff base ligands derived from di-2-pyridyl ketone exhibit antiproliferative activity in SK-N-MC neuroepithelioma (cancer) cells.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Gergely Szakacs et al.
FEBS letters, 594(23), 3965-3985 (2020-10-25)
ABC transporters fulfill diverse physiological functions in different cellular localizations ranging from the plasma membrane to intracellular membranous compartments. Several ABC transporters have been spotted in the endolysosomal system, which consists of endosomes, autophagosomes, lysosomes, and lysosome-related organelles. In this
Maram T Basha et al.
Dalton transactions (Cambridge, England : 2003), 41(21), 6536-6548 (2012-03-01)
The iron coordination and biological chemistry of a series of heterocyclic dithiocarbazate Schiff base ligands is reported with regard to their activity as Fe chelators for the treatment of Fe overload and also cancer. The ligands are analogous to tridentate
Hana Jansová et al.
Current medicinal chemistry, 26(2), 288-301 (2017-09-22)
Heart is a particularly sensitive organ to iron overload and cardiomyopathy due to the excessive cardiac iron deposition causes most deaths in disorders such as beta-thalassemia major. Free or loosely bound iron ions readily cycle between ferrous and ferric states
Joanna Masternak et al.
Materials (Basel, Switzerland), 13(16) (2020-08-14)
The oncological use of cisplatin is hindered by its severe side effects and a very important resistance problem. To overcome these problems, scientists have attempted to design new generation transition-metal anticancer complexes. In this study, we present new complexes, ruthenium(II)
Anastasia N Georgopoulou et al.
Dalton transactions (Cambridge, England : 2003), 46(38), 12835-12844 (2017-09-19)
The reaction of mixtures of Fe(O
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