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Merck
CN

139114

(−)-Borneol

predominantly endo, 97%

Synonym(s):

endo-(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol

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About This Item

Empirical Formula (Hill Notation):
C10H18O
CAS Number:
464-45-9
Molecular Weight:
154.25
UNSPSC Code:
12352212
NACRES:
NA.22
PubChem Substance ID:
24848391
EC Number:
207-353-1
Beilstein/REAXYS Number:
2038053
MDL number:
MFCD00003759
Assay:
97%
Form:
solid

Key Documents

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Product Name

(−)-Borneol, predominantly endo, 97%

assay

97%

form

solid

InChI key

DTGKSKDOIYIVQL-QXFUBDJGSA-N

InChI

1S/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3/t7-,8+,10+/m0/s1

SMILES string

[H][C@]12CC[C@](C)([C@H](O)C1)C2(C)C

vapor density

5.31 (vs air)

vapor pressure

33.5 mmHg ( 25 °C)

optical activity

[α]20/D −35.3°, c = 5 in ethanol

bp

210 °C (lit.)

mp

206-208 °C (lit.)

functional group

hydroxyl

Quality Level

100

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Application

(-)-Borneol has been used to study its antiapoptotic, antioxidative and neuroprotective effect in human neuroblastoma cells (SH-SY5Y).

General description

(-)-Borneol is a bicyclic monoterpene found in essential oils.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 3 - Flam. Sol. 2 - Skin Sens. 1

Storage Class

4.1B - Flammable solid hazardous materials

wgk

WGK 2

flash_point_f

150.8 °F

flash_point_c

66 °C

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
STBK1979
STBJ9364
STBH6980
STBG2379V
STBF3146V

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(+)-And (-)-borneol: efficacious positive modulators of GABA action at human recombinant a 1 ? 2 ? 2L GABA A receptors.
Granger RE, et al.
Biochemical Pharmacology, 69(7), 1101-1111 (2005)
Jinyoung Hur et al.
Pharmaceutical biology, 51(1), 30-35 (2012-11-09)
The β-amyloid (Aβ) peptide aggregation with accompanying oxidative stress plays the major role in the pathogenesis of Alzheimer's disease (AD). Some natural compounds, including borneol, shed promising light on AD treatment. The present study was designed to investigate the antioxidative
Zhen-Yu Xiong et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(6), 786-790 (2013-05-31)
Borneol is a major component of many medicinal plant essential oils, as well as a popular traditional Chinese medicine. This essay collects the results of the latest domestic and foreign studies, and summarizes and analyzes its activity and reaction mechanism
Jingjing Liu et al.
European journal of pharmacology, 688(1-3), 1-5 (2011-12-28)
The bioavailabilities of eye drops are very low, so it is eager to find a safe and effective penetration enhancer to improve drug bioavailability. In our study, the corneas of New Zealand albino rabbit were mounted in the improved Franz
Xiao Song et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(18), 2489-2492 (2012-01-20)
To investigate the absorption characteristic of borneol. Using single pass perfusion model, the active ingredient of borneol were detected by GC. The drug concentration, perfusion rate and pH value on the absorption of borneol were studied. Perfusion rate on the
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