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Merck
CN

143634

p-Tolyl isocyanate

99%

Synonym(s):

4-Methylphenyl isocyanate

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About This Item

Linear Formula:
CH3C6H4NCO
CAS Number:
622-58-2
Molecular Weight:
133.15
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24848599
EC Number:
210-743-4
Beilstein/REAXYS Number:
471494
MDL number:
MFCD00002029
Assay:
99%
Form:
liquid

Key Documents

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Product Name

p-Tolyl isocyanate, 99%

InChI key

MGYGFNQQGAQEON-UHFFFAOYSA-N

InChI

1S/C8H7NO/c1-7-2-4-8(5-3-7)9-6-10/h2-5H,1H3

SMILES string

Cc1ccc(cc1)N=C=O

assay

99%

form

liquid

refractive index

n20/D 1.531 (lit.)

bp

70-72 °C/10 mmHg (lit.)

density

1.056 g/mL at 25 °C (lit.)

functional group

isocyanate

storage temp.

2-8°C

Quality Level

100

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Application

p-Tolyl isocyanate was used to study the catalytic role of supported Rhodium(I) complex toward the reductive carbonylation of nitrobenzene in DMF medium.

General description

p-Tolyl isocyanate reacts with human serum albumin to form antigen which helps in detecting IgE antibodies in workers hypersensitive to toluene diisocyanate.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1C - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

150.8 °F - closed cup

flash_point_c

66 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ3001
MKCZ0761
MKCW0033
MKCV3566
MKCQ8203

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K S Tse et al.
Allergy, 40(5), 314-320 (1985-07-01)
The prevalence of sensitization was studied in a group of 76 foundry workers with occupational exposure to diphenylmethane diisocyanate (MDI). Ten workers had clinical evidence of asthma, 40 had non-asthmatic respiratory symptoms, and 26 were asymptomatic. Specific IgE antibodies to
Johannes Lenz et al.
Polymers, 11(8) (2019-07-31)
A series of new flame retardants (FR) based on dibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide (BPPO) incorporating acrylates and benzoquinone were developed previously. In this study, we examine the fire behavior of the new flame retardants in polyisocyanurate (PIR) foams. The foam characteristics, thermal
Catalytic Activity of Supported Rhodium (I) Complex for the Carbonylation of Nitrobenzene: Mechanism for Carbamate Formation.
Kim JH, et al.
Bull. Korean Chem. Soc., 31(6), 1621-1627 (2010)
K C Chang et al.
Clinical allergy, 14(4), 329-339 (1984-07-01)
A worker developed two episodes of severe asthma 90 min after cutting a polyurethane plate made of diphenylmethane diisocyanate (MDI) using a rapidly turning carbide blade. Intradermal skin testing with MDI-human serum albumin (MDI-HSA) and p-tolyl isocyanate-HSA (p-TMI-HSA) were positive
C J Game
American Industrial Hygiene Association journal, 43(10), 759-763 (1982-10-01)
Sera of 91 people were assayed for IgE which bound to a p-tolyl-isocyanate-human serum albumin conjugate. The sera came from 20 blood donors, 70 factory workers, and 1 casualty patient. Three factory workers had abnormally high assay values in association
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